| Literature DB >> 26762386 |
Hiroki Shinkai1, Daisuke Toki2, Naohiko Okumura2, Takato Takenouchi1, Hiroshi Kitani1, Hirohide Uenishi3,4.
Abstract
Dectin-1, a C-type lectin receptor that recognizes fungal β-glucans, is involved in antifungal immunity and the regulation of intestinal immune homeostasis. Dectin-1 is involved in both synthesis and maturation of interleukin-1β, a key pro-inflammatory cytokine in immunity. Here, we assessed the genetic diversity in the gene encoding dectin-1 (CLEC7A) within various pig populations and examined the influence of these polymorphisms on the two different signaling pathways after ligand recognition. An amino-acid polymorphism located in the carbohydrate-recognition domain, leucine to serine at position 138 (L138S), which occurred exclusively in Japanese wild boars at low frequency, significantly increased NF-κB induction but not caspase-8 activity after stimulation with zymosan. In contrast, other amino-acid polymorphisms present at comparatively high frequency in commercial pig populations had little influence on ligand recognition. These results suggest that functionally neutral polymorphisms in dectin-1 are widespread in pig populations.Entities:
Keywords: Caspase-8; Dectin-1; NF-κB; Pig; Single nucleotide polymorphism (SNP)
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Year: 2016 PMID： 26762386 DOI： 10.1007/s00251-016-0900-7
Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846