Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal.

Literature DB >> 26762270

Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal.

Abstract

CaMKII is a serine-threonine protein kinase that is abundant in myocardium. Emergent evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) by targeting a diverse array of proteins involved in membrane excitability, cell survival, calcium homeostasis, matrix remodelling, inflammation, and metabolism. Furthermore, CaMKII inhibition appears to protect against AF in animal models and correct proarrhythmic, defective intracellular Ca(2+) homeostasis in fibrillating human atrial cells. This review considers current concepts and evidence from animal and human studies on the role of CaMKII in AF. Published on behalf of the European Society of Cardiology. All rights reserved.

Entities: Chemical Disease Gene Species

Keywords: Arrhythmias; Atrial fibrillation; Atrial remodelling; CaMKII

Mesh：

Substances：

Year: 2016 PMID： 26762270 PMCID： PMC4777912 DOI： 10.1093/cvr/cvw002

Source DB: PubMed Journal: Cardiovasc Res ISSN： 0008-6363 Impact factor: 10.787

231 in total

1. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

Authors: S O Marx; S Reiken; Y Hisamatsu; T Jayaraman; D Burkhoff; N Rosemblit; A R Marks
Journal: Cell Date: 2000-05-12 Impact factor: 41.582

2. CaMKII inhibition in heart failure, beneficial, harmful, or both.

Authors: Jun Cheng; Lin Xu; Dongwu Lai; Arnaud Guilbert; Hyun Joung Lim; Thitima Keskanokwong; Yanggan Wang
Journal: Am J Physiol Heart Circ Physiol Date: 2012-01-27 Impact factor: 4.733

3. Regulation of the transient outward K(+) current by Ca(2+)/calmodulin-dependent protein kinases II in human atrial myocytes.

Authors: S Tessier; P Karczewski; E G Krause; Y Pansard; C Acar; M Lang-Lazdunski; J J Mercadier; S N Hatem
Journal: Circ Res Date: 1999-10-29 Impact factor: 17.367

4. Passive and active tension in single cardiac myofibrils.

Authors: W A Linke; V I Popov; G H Pollack
Journal: Biophys J Date: 1994-08 Impact factor: 4.033

5. Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes.

Authors: Yanxia Li; Evangelia G Kranias; Gregory A Mignery; Donald M Bers
Journal: Circ Res Date: 2002-02-22 Impact factor: 17.367

6. Defective cardiac ryanodine receptor regulation during atrial fibrillation.

Authors: John A Vest; Xander H T Wehrens; Steven R Reiken; Stephan E Lehnart; Dobromir Dobrev; Parag Chandra; Peter Danilo; Ursula Ravens; Michael R Rosen; Andrew R Marks
Journal: Circulation Date: 2005-04-26 Impact factor: 29.690

7. Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.

Authors: Emily A Oestreich; Sundeep Malik; Sanjeewa A Goonasekera; Burns C Blaxall; Grant G Kelley; Robert T Dirksen; Alan V Smrcka
Journal: J Biol Chem Date: 2008-10-27 Impact factor: 5.157

8. Oxidation- and CaMKII-mediated sarcoplasmic reticulum Ca(2+) leak triggers atrial fibrillation in aging.

Authors: Xiaoxiao Guo; Su Yuan; Zhenyu Liu; Quan Fang
Journal: J Cardiovasc Electrophysiol Date: 2014-05-02

9. A slowly inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes.

Authors: Yejia Song; John C Shryock; Luiz Belardinelli
Journal: Am J Physiol Heart Circ Physiol Date: 2009-08-21 Impact factor: 4.733

10. Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes.

Authors: M E Anderson; A P Braun; H Schulman; B A Premack
Journal: Circ Res Date: 1994-11 Impact factor: 17.367

19 in total

1. Deciphering the fundamental mechanisms of atrial fibrillation: a quest for over a century.

Authors: Stanley Nattel; Dobromir Dobrev
Journal: Cardiovasc Res Date: 2016-02-07 Impact factor: 10.787

Review 2. Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy: A Translational Perspective.

Authors: Stanley Nattel; Jordi Heijman; Liping Zhou; Dobromir Dobrev
Journal: Circ Res Date: 2020-06-18 Impact factor: 17.367

3. Mechanisms of in utero cortisol effects on the newborn heart revealed by transcriptomic modeling.

Authors: Andrew Antolic; Mengchen Li; Elaine M Richards; Celia W Curtis; Charles E Wood; Maureen Keller-Wood
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2019-01-09 Impact factor: 3.619

4. Oxidative stress creates a unique, CaMKII-mediated substrate for atrial fibrillation in heart failure.

Authors: Shin Yoo; Gary Aistrup; Yohannes Shiferaw; Jason Ng; Peter J Mohler; Thomas J Hund; Trent Waugh; Suzanne Browne; Georg Gussak; Mehul Gilani; Bradley P Knight; Rod Passman; Jeffrey J Goldberger; J Andrew Wasserstrom; Rishi Arora
Journal: JCI Insight Date: 2018-11-02

5. Genetic insight into sick sinus syndrome.

Authors: Rosa B Thorolfsdottir; Gardar Sveinbjornsson; Hildur M Aegisdottir; Stefania Benonisdottir; Lilja Stefansdottir; Erna V Ivarsdottir; Gisli H Halldorsson; Jon K Sigurdsson; Christian Torp-Pedersen; Peter E Weeke; Søren Brunak; David Westergaard; Ole B Pedersen; Erik Sorensen; Kaspar R Nielsen; Kristoffer S Burgdorf; Karina Banasik; Ben Brumpton; Wei Zhou; Asmundur Oddsson; Vinicius Tragante; Kristjan E Hjorleifsson; Olafur B Davidsson; Sridharan Rajamani; Stefan Jonsson; Bjarni Torfason; Atli S Valgardsson; Gudmundur Thorgeirsson; Michael L Frigge; Gudmar Thorleifsson; Gudmundur L Norddahl; Anna Helgadottir; Solveig Gretarsdottir; Patrick Sulem; Ingileif Jonsdottir; Cristen J Willer; Kristian Hveem; Henning Bundgaard; Henrik Ullum; David O Arnar; Unnur Thorsteinsdottir; Daniel F Gudbjartsson; Hilma Holm; Kari Stefansson
Journal: Eur Heart J Date: 2021-05-21 Impact factor: 29.983

10. Description of the Human Atrial Action Potential Derived From a Single, Congruent Data Source: Novel Computational Models for Integrated Experimental-Numerical Study of Atrial Arrhythmia Mechanisms.

Authors: Michael A Colman; Priyanka Saxena; Sarah Kettlewell; Antony J Workman
Journal: Front Physiol Date: 2018-09-07 Impact factor: 4.566