Jungo Imanishi1, Yasuo Yazawa2, Tsuyoshi Saito3, Michio Shimizu4, Hiroyuki Kawashima5, Keisuke Ae6, Akihiko Matsumine7, Tomoaki Torigoe8, Hideshi Sugiura9,10, Susumu Joyama11,12. 1. Department of Orthopaedic Oncology and Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan. jungo@saitama-med.ac.jp. 2. Department of Orthopaedic Oncology and Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan. 3. Department of Human Pathology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan. 4. Diagnostic Pathology Center, Hakujikai Memorial Hospital, 5-11-1 Shikahama, Adachi-ku, Tokyo, 123-0864, Japan. 5. Department of Orthopaedic Surgery, Niigata University Medical and Dental Hospital, 754, Ichibancho, Asahimachidori, Chuo-ku, Niigata, Niigata, 951-8510, Japan. 6. Department of Orthopaedic Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. 7. Department of Orthopedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. 8. Department of Orthopaedic Surgery, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421, Japan. 9. Department of Orthopaedic Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Nagoya, 464-8681, Japan. 10. Department of Physical Therapy, Nagoya University School of Health Sciences, 1-1-20 Daiko-minami, Higashi-ku, Nagoya, Aichi, 461-8673, Japan. 11. Department of Orthopaedic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka, Osaka, 537-8511, Japan. 12. Department of Orthopaedic Surgery, Kawachi General Hospital, 1-31 Yokomakura, Higashiosaka, Osaka, 578-0954, Japan.
Abstract
BACKGROUND: Malignant granular cell tumors (MGCTs) are extremely rare neoplasms with only a limited number of studies published to date. The aim of this study is to elucidate the clinicopathological characteristics and prognostic factors of MGCTs. METHODS: This is a multi-institutional retrospective study of MGCTs with a central pathological review. A total of 18 cases were retrieved. Specimens were blindly reviewed by two pathologists based on the diagnostic criteria by Fanburg-Smith et al. Kaplan-Meier survival probabilities were calculated, and risk factors for poor prognosis were evaluated. RESULTS: Three and fifteen cases were diagnosed as atypical GCTs (AGCTs) and mGCTs according to the Fanburg-Smith et al. classification, respectively. Four (one atypical and three malignant) cases had metastasis at the first presentation, including lymph node metastasis. Three out of ten cases treated with wide resection developed local recurrence. Although prolonged static disease periods of ≥1 year were observed in four cases receiving chemotherapy, all cases with local recurrence or metastasis, including two atypical cases, eventually died of disease. The 5- and 10-year overall survival rates for localized MGCTs were 69.2 and 34.6 %, respectively. The presence of necrosis was revealed as a risk factor associated with adverse clinical outcomes. CONCLUSIONS: MGCTs have high rates of recurrence and metastasis including lymph node metastasis. As histologically atypical cases also have metastatic potential, close attention should be paid to AGCTs. The combination of histological evaluation and tumor size may lead to more accurate diagnosis of this rare neoplasm.
BACKGROUND:Malignant granular cell tumors (MGCTs) are extremely rare neoplasms with only a limited number of studies published to date. The aim of this study is to elucidate the clinicopathological characteristics and prognostic factors of MGCTs. METHODS: This is a multi-institutional retrospective study of MGCTs with a central pathological review. A total of 18 cases were retrieved. Specimens were blindly reviewed by two pathologists based on the diagnostic criteria by Fanburg-Smith et al. Kaplan-Meier survival probabilities were calculated, and risk factors for poor prognosis were evaluated. RESULTS: Three and fifteen cases were diagnosed as atypical GCTs (AGCTs) and mGCTs according to the Fanburg-Smith et al. classification, respectively. Four (one atypical and three malignant) cases had metastasis at the first presentation, including lymph node metastasis. Three out of ten cases treated with wide resection developed local recurrence. Although prolonged static disease periods of ≥1 year were observed in four cases receiving chemotherapy, all cases with local recurrence or metastasis, including two atypical cases, eventually died of disease. The 5- and 10-year overall survival rates for localized MGCTs were 69.2 and 34.6 %, respectively. The presence of necrosis was revealed as a risk factor associated with adverse clinical outcomes. CONCLUSIONS: MGCTs have high rates of recurrence and metastasis including lymph node metastasis. As histologically atypical cases also have metastatic potential, close attention should be paid to AGCTs. The combination of histological evaluation and tumor size may lead to more accurate diagnosis of this rare neoplasm.
Authors: Payal Kapur; Dinesh Rakheja; Jyoti P Balani; Lonnie C Roy; Robin H Amirkhan; Mai P Hoang Journal: Arch Pathol Lab Med Date: 2007-01 Impact factor: 5.534
Authors: J M Coindre; P Terrier; N B Bui; F Bonichon; F Collin; V Le Doussal; A M Mandard; M O Vilain; J Jacquemier; H Duplay; X Sastre; C Barlier; M Henry-Amar; J Macé-Lesech; G Contesso Journal: J Clin Oncol Date: 1996-03 Impact factor: 44.544
Authors: J Cruz-Mojarrieta; S Navarro; E Goméz-Cabrera; L Peréz-Peña; P Soriano; A Peydró-Oyala; A Llombart-Bosch Journal: Int J Surg Pathol Date: 2001-07 Impact factor: 1.271
Authors: N Tawfiq; S Sabri; K Saiss; Z Bouchbika; N Benchekroun; H Jouhadi; S Sahraoui; A Benider Journal: Cancer Radiother Date: 2013-10-30 Impact factor: 1.018
Authors: C Marchand Crety; C Garbar; G Madelis; F Guillemin; P Soibinet Oudot; J C Eymard; S Servagi Vernat Journal: Radiat Oncol Date: 2018-06-20 Impact factor: 3.481