| Literature DB >> 26761401 |
Shivani Sharma1, Ramdas S Pathare1, Antim K Maurya1, Kandasamy Gopal1, Tapta Kanchan Roy1, Devesh M Sawant1, Ram T Pardasani1.
Abstract
A ruthenium catalyzed intramolecular C-S coupling reaction of N-arylthioureas for the synthesis of 2-aminobenzothiazoles has been developed. Kinetic, isotope labeling, and computational studies reveal the involvement of an electrophilic ruthenation pathway instead of a direct C-H activation. Stereoelectronic effect of meta-substituents on the N-arylthiourea dictates the final regioselective outcome of the reaction.Entities:
Year: 2016 PMID： 26761401 DOI： 10.1021/acs.orglett.5b03185
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005