Literature DB >> 26760951

Automated radiosynthesis of [(11)C]L-deprenyl-D2 and [(11)C]D-deprenyl using a commercial platform.

Pablo Buccino1, Ingrid Kreimerman1, Kevin Zirbesegger1, Williams Porcal2, Eduardo Savio3, Henry Engler1.   

Abstract

Two (11)C-labelled PET tracers, (R)-N-[(11)C]methyl-N-(3,3-dideuteropropargyl)-1-phenylpropan-2-amine ([(11)C]L-deprenyl-D2, [(11)C]DED) and (S)-N-[(11)C]methyl-N-propargyl-1-phenylpropan-2-amine ([(11)C]D-deprenyl, [(11)C]DDE) were synthesised. One step N-alkylation with [(11)C]MeI or [(11)C]MeOTf was performed using the automated platform TRACERlab® FX-C Pro. The labelled products were obtained with (37±15)% (n=10) (end of synthesis, decay corrected from [(11)C]MeI) radiochemical yields from [(11)C]MeI after 38±3min synthesis time. In all cases, radiochemical purity was over 99% when [(11)C]MeOTf was used. This synthesis using a commercial platform makes these tracers more accessible for clinical research purposes.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Automated synthesis; PET chemistry; [(11)C]D-deprenyl; [(11)C]L-deprenyl-D(2)

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Year:  2015        PMID： 26760951     DOI： 10.1016/j.apradiso.2015.12.051

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  2 in total

1.  An efficient preparation of labelling precursor of [11C]L-deprenyl-D2 and automated radiosynthesis.

Authors:  Kevin Zirbesegger; Pablo Buccino; Ingrid Kreimerman; Henry Engler; Williams Porcal; Eduardo Savio
Journal:  EJNMMI Radiopharm Chem       Date:  2017-07-24

2.  Automated One-pot Radiosynthesis of [11C]S-adenosyl Methionine.

Authors:  Florencia Zoppolo; Williams Porcal; Patricia Oliver; Eduardo Savio; Henry Engler
Journal:  Curr Radiopharm       Date:  2017-11-10
  2 in total

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