Muhammad Salman1, Amer Hayat Khan2, Azreen Syazril Adnan3, Syed Azhar Syed Sulaiman2, Khalid Hussain4, Naureen Shehzadi4, Fauziah Jummaat5. 1. Department of Pharmacy Practice, University College of Pharmacy, University of the Punjab, Lahore-54000, Pakistan. 2. School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia. 3. Chronic Kidney Disease Resource Centre, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia. 4. University College of Pharmacy, University of the Punjab, Lahore-54000, Pakistan. 5. Department of Gynecology and Obstetrics, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
Abstract
CONTEXT AND OBJECTIVE: Chronic kidney disease (CKD) is an escalating medical and socioeconomic problem worldwide. Information concerning the causes of CKD, which is a prerequisite for reducing the disease burden, is sparse in Malaysia. Therefore, this study aimed to evaluate the attributable causes of CKD in an adult population at a tertiary referral hospital. DESIGN AND SETTING: Retrospective study at Hospital Universiti Sains Malaysia (HUSM). METHODS: This was an analysis based on medical records of adult patients at HUSM. Data regarding demographics, laboratory investigations, attributable causes and CKD stage were gathered. RESULTS: A total of 851 eligible cases were included. The patients' mean age was 61.18 ± 13.37 years. CKD stage V was found in 333 cases (39.1%) whereas stages IV, IIIb, IIIa, and II were seen in 240 (28.2%), 186 (21.9%), 74 (8.7%) and 18 (2.1%), respectively. The percentage of CKD stage V patients receiving renal replacement therapy was 15.6%. The foremost attributable causes of CKD were diabetic nephropathy (DN) (44.9%), hypertension (HPT) (24.2%) and obstructive uropathy (9.2%). The difference in the prevalence of CKD due to DN, HPT and glomerulonephritis between patients ≤ 50 and > 50 years old was statistically significant. CONCLUSION: Our results suggest that DN and HPT are the major attributable causes of CKD among patients at a Malaysian tertiary-care hospital. Furthermore, the results draw attention to the possibility that greater emphasis on primary prevention of diabetes and hypertension will have a great impact on reduction of hospital admissions due to CKD in Malaysia.
CONTEXT AND OBJECTIVE:Chronic kidney disease (CKD) is an escalating medical and socioeconomic problem worldwide. Information concerning the causes of CKD, which is a prerequisite for reducing the disease burden, is sparse in Malaysia. Therefore, this study aimed to evaluate the attributable causes of CKD in an adult population at a tertiary referral hospital. DESIGN AND SETTING: Retrospective study at Hospital Universiti Sains Malaysia (HUSM). METHODS: This was an analysis based on medical records of adult patients at HUSM. Data regarding demographics, laboratory investigations, attributable causes and CKD stage were gathered. RESULTS: A total of 851 eligible cases were included. The patients' mean age was 61.18 ± 13.37 years. CKD stage V was found in 333 cases (39.1%) whereas stages IV, IIIb, IIIa, and II were seen in 240 (28.2%), 186 (21.9%), 74 (8.7%) and 18 (2.1%), respectively. The percentage of CKD stage V patients receiving renal replacement therapy was 15.6%. The foremost attributable causes of CKD were diabetic nephropathy (DN) (44.9%), hypertension (HPT) (24.2%) and obstructive uropathy (9.2%). The difference in the prevalence of CKD due to DN, HPT and glomerulonephritis between patients ≤ 50 and > 50 years old was statistically significant. CONCLUSION: Our results suggest that DN and HPT are the major attributable causes of CKD among patients at a Malaysian tertiary-care hospital. Furthermore, the results draw attention to the possibility that greater emphasis on primary prevention of diabetes and hypertension will have a great impact on reduction of hospital admissions due to CKD in Malaysia.
Authors: Ambigga Krishnapillai; Mohd Azahadi Omar; Suthahar Ariaratnam; Smaria Awaluddin; Rajini Sooryanarayana; Ho Bee Kiau; Noorlaili Mohd Tauhid; Sazlina Shariff Ghazali Journal: Int J Environ Res Public Health Date: 2022-04-20 Impact factor: 4.614
Authors: Rodrigo M Carrillo-Larco; Carlos Altez-Fernandez; J Gonzalo Acevedo-Rodriguez; Karol Ortiz-Acha; Cesar Ugarte-Gil Journal: PLoS Negl Trop Dis Date: 2019-05-23