| Literature DB >> 26759497 |
Marisa Holubar1, Stephanie B Troy2, Kusum Nathoo3, Lynda Stranix-Chibanda3,4, Georgina Musingwini4, Nivedita Srinivas1, ChunHong Huang1, Alexandra Junn5, Meira S Halpern1, Yvonne A Maldonado1,4.
Abstract
Community circulation of oral poliovirus vaccine (OPV) likely begins with household transmission. We analyzed stool collected from Zimbabwean mothers who were infected with human immunodeficiency virus (HIV) and those who were uninfected with HIV 1 to 24 weeks after infant oral poliovirus vaccination. Overall, only 5% of the mothers had detectable OPV (16 of 304) despite high infant shedding rates. OPV shedding was similar between HIV-infected mothers and those who were uninfected (11 [6.4%] of 171 vs 5 [3.8%] of 133, respectively) and between mothers of HIV-infected infants and those of uninfected infants (2 [3.5%] of 57 vs 9 [6.3%] of 144, respectively). Mothers of vaccinated infants are unlikely to shed OPV, even when they are infected with HIV. © Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.Entities:
Keywords: OPV; OPV shedding; contact shedding of OPV; oral poliovirus vaccine; poliovirus transmission
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Year: 2017 PMID： 26759497 PMCID： PMC5907849 DOI： 10.1093/jpids/piv083
Source DB: PubMed Journal: J Pediatric Infect Dis Soc ISSN： 2048-7193 Impact factor: 3.164