Stefano Parodi1, Irene Santi2, Enza Marani3, Claudia Casella3, Antonella Puppo3, Elsa Garrone4, Vincenzo Fontana5, Emanuele Stagnaro6,7. 1. Institute of Electronics, Computer and Telecommunication Engineering, National Research Council of Italy, Via De Marini, 6, 16149, Genoa, Italy. 2. AO Clinical Investigation and Documentation (AOCID), Stettbachstrasse 6, 8600, Dübendorf, Switzerland. 3. Liguria Cancer Registry, IRCCS AOU San Martino-IST National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132, Genoa, Italy. 4. Liguria Mortality Registry, IRCCS AOU San Martino-IST National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132, Genoa, Italy. 5. Unit of Clinical Epidemiology, IRCCS AOU San Martino-IST National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132, Genoa, Italy. 6. Liguria Mortality Registry, IRCCS AOU San Martino-IST National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132, Genoa, Italy. emanuele.stagnaro@hsanmartino.it. 7. Unit of Clinical Epidemiology, IRCCS AOU San Martino-IST National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132, Genoa, Italy. emanuele.stagnaro@hsanmartino.it.
Abstract
PURPOSE: Risk factors for leukemia and lymphomas in adults are largely unknown. This study was aimed at evaluating the association between lifestyle factors and the risk of hematological malignancies in an adult population. METHODS: Data were drawn from a population-based case-control study carried out in Italy and included 294 cases (199 lymphoid and 95 myeloid) and 279 controls. Analyses were performed using standard multivariable logistic regression. RESULTS: Hair dye use for at least 15 years was associated with a higher risk of lymphoid malignancies among females (OR 2.3, 95 % CI 1.0-4.9, p = 0.036, test for trend). Furthermore, a protective effect of a moderate to heavy tea consumption on the risk of myeloid malignancies was observed (OR 0.4, 95 % CI 0.2-0.9, p = 0.017). No association was found for the use of alcoholic beverages and tobacco smoking. CONCLUSIONS: Our results confirm the potential carcinogenic effect of prolonged hair dye use observed in previous investigations. The excess risk could be explained by exposure to a higher concentration of toxic compounds in hair products used in the past. The protective effect of regular tea consumption observed in an area with a very high prevalence of black tea consumers deserves further investigation.
PURPOSE: Risk factors for leukemia and lymphomas in adults are largely unknown. This study was aimed at evaluating the association between lifestyle factors and the risk of hematological malignancies in an adult population. METHODS: Data were drawn from a population-based case-control study carried out in Italy and included 294 cases (199 lymphoid and 95 myeloid) and 279 controls. Analyses were performed using standard multivariable logistic regression. RESULTS: Hair dye use for at least 15 years was associated with a higher risk of lymphoid malignancies among females (OR 2.3, 95 % CI 1.0-4.9, p = 0.036, test for trend). Furthermore, a protective effect of a moderate to heavy tea consumption on the risk of myeloid malignancies was observed (OR 0.4, 95 % CI 0.2-0.9, p = 0.017). No association was found for the use of alcoholic beverages and tobacco smoking. CONCLUSIONS: Our results confirm the potential carcinogenic effect of prolonged hair dye use observed in previous investigations. The excess risk could be explained by exposure to a higher concentration of toxic compounds in hair products used in the past. The protective effect of regular tea consumption observed in an area with a very high prevalence of black tea consumers deserves further investigation.
Authors: R A Filiberti; V Fontana; A De Ceglie; S Blanchi; E Grossi; D Della Casa; T Lacchin; M De Matthaeis; O Ignomirelli; R Cappiello; A Rosa; M Foti; F Laterza; V D'Onofrio; G Iaquinto; M Conio Journal: Eur J Clin Nutr Date: 2017-05-10 Impact factor: 4.016
Authors: María Belén Cerliani; Walter Pavicic; Juan Antonio Gili; Graciela Klein; Silvia Saba; Silvina Richard Journal: World J Clin Oncol Date: 2016-10-10