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Literature DB >> 26759318

Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma.

Peter M Clark^1,2, Wilson X Mai^3,4, Timothy F Cloughesy^5,6, David A Nathanson^7,8.

Abstract

Malignant gliomas are intractable and among the most lethal human malignancies. Like other cancers, metabolic reprogramming is a key feature of glioma and is thought to accommodate the heightened nutrient requirements for tumor cell proliferation, growth, and survival. This metabolic rewiring, driven by oncogenic signaling and molded by the unique environment of the brain, may impose vulnerabilities that could be exploited therapeutically for increased tumor control. In this review, we discuss the prominent metabolic features of malignant glioma, the key pathways regulating glioma metabolism, and the potential therapeutic opportunities for targeting metabolic processes.

Entities: Disease Species

Keywords: Glioblastoma; Glioma; Glycolysis; Metabolism; Molecular imaging; Targeted therapy

Mesh：

Year: 2016 PMID： 26759318 DOI： 10.1007/s11910-015-0613-6

Source DB: PubMed Journal: Curr Neurol Neurosci Rep ISSN： 1528-4042 Impact factor: 5.081

93 in total

1. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

Authors: Jiangbin Ye; Anthony Mancuso; Xuemei Tong; Patrick S Ward; Jing Fan; Joshua D Rabinowitz; Craig B Thompson
Journal: Proc Natl Acad Sci U S A Date: 2012-04-16 Impact factor: 11.205

2. Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions.

Authors: Colin R Kennedy; Sarah B Tilkens; Hong Guan; Justine A Garner; Penelope M Y Or; Andrew M Chan
Journal: Cancer Lett Date: 2013-03-21 Impact factor: 8.679

3. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.

Authors: Taro Hitosugi; Sumin Kang; Matthew G Vander Heiden; Tae-Wook Chung; Shannon Elf; Katherine Lythgoe; Shaozhong Dong; Sagar Lonial; Xu Wang; Georgia Z Chen; Jianxin Xie; Ting-Lei Gu; Roberto D Polakiewicz; Johannes L Roesel; Titus J Boggon; Fadlo R Khuri; D Gary Gilliland; Lewis C Cantley; Jonathan Kaufman; Jing Chen
Journal: Sci Signal Date: 2009-11-17 Impact factor: 8.192

4. mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc.

Authors: Kenta Masui; Kazuhiro Tanaka; David Akhavan; Ivan Babic; Beatrice Gini; Tomoo Matsutani; Akio Iwanami; Feng Liu; Genaro R Villa; Yuchao Gu; Carl Campos; Shaojun Zhu; Huijun Yang; William H Yong; Timothy F Cloughesy; Ingo K Mellinghoff; Webster K Cavenee; Reuben J Shaw; Paul S Mischel
Journal: Cell Metab Date: 2013-10-17 Impact factor: 27.287

5. Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors.

Authors: Igor Vivanco; H Ian Robins; Daniel Rohle; Carl Campos; Christian Grommes; Phioanh Leia Nghiemphu; Sara Kubek; Barbara Oldrini; Milan G Chheda; Nicolas Yannuzzi; Hui Tao; Shaojun Zhu; Akio Iwanami; Daisuke Kuga; Julie Dang; Alicia Pedraza; Cameron W Brennan; Adriana Heguy; Linda M Liau; Frank Lieberman; W K Alfred Yung; Mark R Gilbert; David A Reardon; Jan Drappatz; Patrick Y Wen; Kathleen R Lamborn; Susan M Chang; Michael D Prados; Howard A Fine; Steve Horvath; Nian Wu; Andrew B Lassman; Lisa M DeAngelis; William H Yong; John G Kuhn; Paul S Mischel; Minesh P Mehta; Timothy F Cloughesy; Ingo K Mellinghoff
Journal: Cancer Discov Date: 2012-03-31 Impact factor: 39.397

6. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

Authors: Peppi Koivunen; Sungwoo Lee; Christopher G Duncan; Giselle Lopez; Gang Lu; Shakti Ramkissoon; Julie A Losman; Päivi Joensuu; Ulrich Bergmann; Stefan Gross; Jeremy Travins; Samuel Weiss; Ryan Looper; Keith L Ligon; Roel G W Verhaak; Hai Yan; William G Kaelin
Journal: Nature Date: 2012-02-15 Impact factor: 49.962

7. Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death.

Authors: Nicholas A Graham; Martik Tahmasian; Bitika Kohli; Evangelia Komisopoulou; Maggie Zhu; Igor Vivanco; Michael A Teitell; Hong Wu; Antoni Ribas; Roger S Lo; Ingo K Mellinghoff; Paul S Mischel; Thomas G Graeber
Journal: Mol Syst Biol Date: 2012-06-26 Impact factor: 11.429

8. Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme.

Authors: Amparo Wolf; Sameer Agnihotri; Johann Micallef; Joydeep Mukherjee; Nesrin Sabha; Rob Cairns; Cynthia Hawkins; Abhijit Guha
Journal: J Exp Med Date: 2011-01-17 Impact factor: 14.307

9. Comprehensive genomic characterization defines human glioblastoma genes and core pathways.

Authors:
Journal: Nature Date: 2008-09-04 Impact factor: 49.962

10. High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss.

Authors: S Oudard; F Arvelo; L Miccoli; F Apiou; A M Dutrillaux; M Poisson; B Dutrillaux; M F Poupon
Journal: Br J Cancer Date: 1996-09 Impact factor: 7.640

9 in total

1. Glioma targeting peptide in combination with the P53 C terminus inhibits glioma cell proliferation in vitro.

Authors: Dan Wang; Meihua Guo; Jiawen Yu; Xinying Wang; Qian Zhang; Xu Yang; Jiaqi Li; Chunhui Zhao; Bin Feng
Journal: Cytotechnology Date: 2017-09-06 Impact factor: 2.058

Review 2. Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy.

Authors: Eric C Woolf; Nelofer Syed; Adrienne C Scheck
Journal: Front Mol Neurosci Date: 2016-11-16 Impact factor: 5.639

3. Multivoxel magnetic resonance spectroscopy identifies enriched foci of cancer stem-like cells in high-grade gliomas.

Authors: Tao He; Tianming Qiu; Xiaodong Wang; Hongxing Gui; Xilong Wang; Qikuan Hu; Hechun Xia; Gaoyang Qi; Jinsong Wu; Hui Ma
Journal: Onco Targets Ther Date: 2017-01-04 Impact factor: 4.147

Review 4. Metabolic Reprogramming in Glioma.

Authors: Marie Strickland; Elizabeth A Stoll
Journal: Front Cell Dev Biol Date: 2017-04-26

5. Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.

Authors: Nathan P Ward; Angela M Poff; Andrew P Koutnik; Dominic P D'Agostino
Journal: PLoS One Date: 2017-06-23 Impact factor: 3.240

6. A quantitative SVM approach potentially improves the accuracy of magnetic resonance spectroscopy in the preoperative evaluation of the grades of diffuse gliomas.

Authors: Chong Qi; Yiming Li; Xing Fan; Yin Jiang; Rui Wang; Song Yang; Lanxi Meng; Tao Jiang; Shaowu Li
Journal: Neuroimage Clin Date: 2019-04-22 Impact factor: 4.881