Tingting Du1, Gang Yuan1, Xinrong Zhou1, Xingxing Sun2. 1. a Department of Endocrinology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China ; 2. b Department of Anesthesiology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
Abstract
OBJECTIVE: Sex differences in the association of HbA1c and cardiovascular disease (CVD) risk remain controversial. We examined CVD risk profile in both HbA1c-defined diabetic and nondiabetic men and women. METHODS: We conducted a cross-sectional analysis of 7139 Chinese adults using data from the China Health and Nutrition Survey 2009. RESULTS: HbA1c-defined nondiabetic men have a more favorable CVD risk profile than female counterparts. However, HbA1c-defined diabetic men have higher levels of triglyceride, low-density lipoprotein (LDL)-cholesterol, and triglyceride/high-density lipoprotein (HDL)-cholesterol and lower levels of HDL-cholesterol, be more visceral obese as indicated by visceral adiposity index (VAI) and lipid accumulation product (LAP), and more insulin resistant as assessed by the triglycerides and glucose index (TyG) than HbA1c-defined diabetic women. Furthermore, HbA1c-defined diabetic men showed greater relative differences in ferritin than diabetic women when compared with their nondiabetic counterparts. Statistically significant sex by HbA1c-defined diabetes status interactions were observed for triglyceride, LDL-cholesterol, HDL-cholesterol, triglyceride/HDL cholesterol, VAI, LAP, TyG, and ferritin (all ps < 0.05). Consideration of VAI or homeostasis model assessment of insulin resistance or both failed to eliminate the sex differences in the associations between diabetes and these CVD risk factors. CONCLUSIONS: Men who progressed from HbA1c-defined nondiabetes to HbA1c-defined diabetes have greater metabolic deteriorations and put on more visceral adiposity than women. Key messages HbA1c-defined nondiabetic men have a more favorable CVD risk profile than female counterparts. Men have to undergo a greater metabolic deterioration to develop HbA1c-defined diabetes than do women. Men have to put on more visceral adiposity to develop HbA1c-defined diabetes than do women.
OBJECTIVE: Sex differences in the association of HbA1c and cardiovascular disease (CVD) risk remain controversial. We examined CVD risk profile in both HbA1c-defined diabetic and nondiabetic men and women. METHODS: We conducted a cross-sectional analysis of 7139 Chinese adults using data from the China Health and Nutrition Survey 2009. RESULTS:HbA1c-defined nondiabetic men have a more favorable CVD risk profile than female counterparts. However, HbA1c-defined diabeticmen have higher levels of triglyceride, low-density lipoprotein (LDL)-cholesterol, and triglyceride/high-density lipoprotein (HDL)-cholesterol and lower levels of HDL-cholesterol, be more visceral obese as indicated by visceral adiposity index (VAI) and lipid accumulation product (LAP), and more insulin resistant as assessed by the triglycerides and glucose index (TyG) than HbA1c-defined diabeticwomen. Furthermore, HbA1c-defined diabeticmen showed greater relative differences in ferritin than diabeticwomen when compared with their nondiabetic counterparts. Statistically significant sex by HbA1c-defined diabetes status interactions were observed for triglyceride, LDL-cholesterol, HDL-cholesterol, triglyceride/HDL cholesterol, VAI, LAP, TyG, and ferritin (all ps < 0.05). Consideration of VAI or homeostasis model assessment of insulin resistance or both failed to eliminate the sex differences in the associations between diabetes and these CVD risk factors. CONCLUSIONS:Men who progressed from HbA1c-defined nondiabetes to HbA1c-defined diabetes have greater metabolic deteriorations and put on more visceral adiposity than women. Key messages HbA1c-defined nondiabetic men have a more favorable CVD risk profile than female counterparts. Men have to undergo a greater metabolic deterioration to develop HbA1c-defined diabetes than do women. Men have to put on more visceral adiposity to develop HbA1c-defined diabetes than do women.
Entities:
Keywords:
Cardiovascular risk factors; HbA1c; diabetes; sex
Authors: Fernando Guerrero-Romero; Luis E Simental-Mendía; Manuel González-Ortiz; Esperanza Martínez-Abundis; María G Ramos-Zavala; Sandra O Hernández-González; Omar Jacques-Camarena; Martha Rodríguez-Morán Journal: J Clin Endocrinol Metab Date: 2010-05-19 Impact factor: 5.958
Authors: Kasia J Lipska; Nathalie De Rekeneire; Peter H Van Ness; Karen C Johnson; Alka Kanaya; Annemarie Koster; Elsa S Strotmeyer; Bret H Goodpaster; Tamara Harris; Thomas M Gill; Silvio E Inzucchi Journal: J Clin Endocrinol Metab Date: 2010-09-22 Impact factor: 5.958
Authors: Elizabeth Selvin; Michael W Steffes; Hong Zhu; Kunihiro Matsushita; Lynne Wagenknecht; James Pankow; Josef Coresh; Frederick L Brancati Journal: N Engl J Med Date: 2010-03-04 Impact factor: 91.245
Authors: Mustafa Kanat; Diedre Winnier; Luke Norton; Nazik Arar; Chris Jenkinson; Ralph A Defronzo; Muhammad A Abdul-Ghani Journal: Diabetes Care Date: 2011-02-23 Impact factor: 19.112
Authors: Rebecca K Simmons; Stephen Sharp; S Matthijs Boekholdt; Lincoln A Sargeant; Kay-Tee Khaw; Nicholas J Wareham; Simon J Griffin Journal: Arch Intern Med Date: 2008-06-09
Authors: Ken Williams; Andre Tchernof; Kelly J Hunt; Lynne E Wagenknecht; Steven M Haffner; Allan D Sniderman Journal: Diabetes Date: 2008-09-22 Impact factor: 9.461