| Literature DB >> 2675840 |
M Shichiri1, Y Hirata, K Kanno, K Ohta, T Emori, F Marumo.
Abstract
Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide with potent pressor activity. We studied the effect of ET-1 on release of arginine-vasopressin (AVP) from perifused rat hypothalamus. ET-1 (10(-10) to 10(-8) M) significantly stimulated AVP release. The ET-1-induced AVP release was completely blocked in the presence of nicardipine. Our results suggest a possible involvement of ET in the regulation of AVP release.Entities:
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Year: 1989 PMID: 2675840 DOI: 10.1016/0006-291x(89)91124-8
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN: 0006-291X Impact factor: 3.575