Literature DB >> 26757905

Role of Sonic Hedgehog (Shh) Signaling in Bladder Cancer Stemness and Tumorigenesis.

Islam S Syed1,2, Akbari Pedram3, Walid A Farhat4.   

Abstract

Sonic hedgehog (Shh) signaling pathway has emerged as a critical component of bladder development, cancer initiation, and progression. While the role of Shh signaling in bladder development is well documented, its role in bladder cancer progression is uncertain. Additionally, epithelial-to-mesenchymal transition (EMT) has been identified to promote bladder cancer progression in the initial stages and also contribute to drug resistance in the later stage and ultimately metastasis. We speculate that epithelial-to-mesenchymal transitions (EMT) and Shh fuel the carcinogenesis process. This review presents the most recent studies focusing on the role of Shh signaling in bladder cancer progression.

Entities:  

Keywords:  Bladder cancer; Regenerative medicine; Sonic hedgehog signaling

Mesh：

Substances：

Year:  2016        PMID： 26757905     DOI： 10.1007/s11934-015-0568-9

Source DB:  PubMed          Journal:  Curr Urol Rep        ISSN： 1527-2737            Impact factor:   3.092


  53 in total

1.  Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells.

Authors:  Suling Liu; Gabriela Dontu; Ilia D Mantle; Shivani Patel; Nam-shik Ahn; Kyle W Jackson; Prerna Suri; Max S Wicha
Journal:  Cancer Res       Date:  2006-06-15       Impact factor: 12.701

2.  Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.

Authors:  Michael F Clarke; John E Dick; Peter B Dirks; Connie J Eaves; Catriona H M Jamieson; D Leanne Jones; Jane Visvader; Irving L Weissman; Geoffrey M Wahl
Journal:  Cancer Res       Date:  2006-09-21       Impact factor: 12.701

3.  Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.

Authors:  Ryuma Haraguchi; Jun Motoyama; Hiroshi Sasaki; Yoshihiko Satoh; Shinichi Miyagawa; Naomi Nakagata; Anne Moon; Gen Yamada
Journal:  Development       Date:  2007-01-03       Impact factor: 6.868

Review 4.  An overview of epithelio-mesenchymal transformation.

Authors:  E D Hay
Journal:  Acta Anat (Basel)       Date:  1995

5.  Hedgehog signaling regulates bladder cancer growth and tumorigenicity.

Authors:  Dennis Liang Fei; Avencia Sanchez-Mejias; Zhiqiang Wang; Colin Flaveny; Jun Long; Samer Singh; Jezabel Rodriguez-Blanco; Robert Tokhunts; Camilla Giambelli; Karoline J Briegel; Wolfgang A Schulz; A Jay Gandolfi; Margaret Karagas; Teresa A Zimmers; Merce Jorda; Pablo Bejarano; Anthony J Capobianco; David J Robbins
Journal:  Cancer Res       Date:  2012-07-19       Impact factor: 12.701

6.  Vertebrate Smoothened functions at the primary cilium.

Authors:  Kevin C Corbit; Pia Aanstad; Veena Singla; Andrew R Norman; Didier Y R Stainier; Jeremy F Reiter
Journal:  Nature       Date:  2005-08-31       Impact factor: 49.962

Review 7.  Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways.

Authors:  Naoko Takebe; Pamela J Harris; Ronald Q Warren; S Percy Ivy
Journal:  Nat Rev Clin Oncol       Date:  2010-12-14       Impact factor: 66.675

8.  Biological heterogeneity of putative bladder cancer stem-like cell populations from human bladder transitional cell carcinoma samples.

Authors:  Angela Bentivegna; Donatella Conconi; Elena Panzeri; Elena Sala; Giorgio Bovo; Paolo Viganò; Silvia Brunelli; Mario Bossi; Giovanni Tredici; Guido Strada; Leda Dalprà
Journal:  Cancer Sci       Date:  2009-10-27       Impact factor: 6.716

9.  A critical role of Sonic Hedgehog signaling in maintaining the tumorigenicity of neuroblastoma cells.

Authors:  Ling Mao; Yuan-Peng Xia; Yu-Nan Zhou; Ruo-Lian Dai; Xue Yang; Shu-Jie Duan; Xian Qiao; Yuan-Wu Mei; Bo Hu; Hongjuan Cui
Journal:  Cancer Sci       Date:  2009-06-26       Impact factor: 6.716

10.  Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development.

Authors:  Kristin R DeSouza; Monalee Saha; Ashley R Carpenter; Melissa Scott; Kirk M McHugh
Journal:  PLoS One       Date:  2013-01-07       Impact factor: 3.240
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  13 in total

1.  Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells.

Authors:  Chun-Peng Liao; Leng-Ying Chen; Andrea Luethy; Youngsoo Kim; Kian Kani; A Robert MacLeod; Mitchell E Gross
Journal:  Endocr Relat Cancer       Date:  2017-04       Impact factor: 5.678

Review 2.  Eradicating Cancer Stem Cells: Concepts, Issues, and Challenges.

Authors:  Gurpreet Kaur; Praveen Sharma; Nilambra Dogra; Sandeep Singh
Journal:  Curr Treat Options Oncol       Date:  2018-03-20

3.  Cell-Intrinsic Tumorigenic Functions of PPARγ in Bladder Urothelial Carcinoma.

Authors:  Danielle J Sanchez; Rindert Missiaen; Nicolas Skuli; David J Steger; M Celeste Simon
Journal:  Mol Cancer Res       Date:  2021-01-11       Impact factor: 6.333

4.  MCT1 regulates aggressive and metabolic phenotypes in bladder cancer.

Authors:  Guiming Zhang; Yongjian Zhang; Dahai Dong; Fangming Wang; Xiaocheng Ma; Fengju Guan; Lijiang Sun
Journal:  J Cancer       Date:  2018-06-15       Impact factor: 4.207

5.  Communication Of Cancer Cells And Lymphatic Vessels In Cancer: Focus On Bladder Cancer.

Authors:  Zhang-Song Wu; Wa Ding; Jiajia Cai; Ghassan Bashir; Yu-Qing Li; Song Wu
Journal:  Onco Targets Ther       Date:  2019-10-03       Impact factor: 4.147

6.  Benzidine promotes the stemness of bladder cancer stem cells via activation of the Sonic hedgehog pathway.

Authors:  Dengdian Wang; Dongdong Xie; Liangkuan Bi; Yi Wang; Ci Zou; Lei Chen; Hao Geng; Weiwei Qian; Yuan Li; Hongliang Sun; Xin Wang; Youlu Lu; Dexin Yu; Caiyun Zhong
Journal:  Oncol Lett       Date:  2020-12-23       Impact factor: 2.967

7.  Propofol Inhibits the Proliferation, Migration, and Stem-like Properties of Bladder Cancer Mainly by Suppressing the Hedgehog Pathway.

Authors:  Gang Li; Xu Zhang; Xiangyang Guo; Yi Li; Chong Li
Journal:  Cell Transplant       Date:  2021 Jan-Dec       Impact factor: 4.064

8.  Astrocytic Sonic Hedgehog Alleviates Intracerebral Hemorrhagic Brain Injury via Modulation of Blood-Brain Barrier Integrity.

Authors:  Gebeili Xing; Tianman Zhao; Xiyue Zhang; He Li; Xiuping Li; Pan Cui; Minshu Li; Daojing Li; Nan Zhang; Wei Jiang
Journal:  Front Cell Neurosci       Date:  2020-12-03       Impact factor: 5.505

Review 9.  Targeting cancer stem cells in cholangiocarcinoma (Review).

Authors:  Nicole A Mcgrath; Jianyang Fu; Sophie Z Gu; Changqing Xie
Journal:  Int J Oncol       Date:  2020-05-28       Impact factor: 5.650

Review 10.  Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer.

Authors:  Amira Abugomaa; Mohamed Elbadawy; Hideyuki Yamawaki; Tatsuya Usui; Kazuaki Sasaki
Journal:  Cells       Date:  2020-01-17       Impact factor: 6.600
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