Anteneh M Feyissa1, Alberto Pochettino2, Thomas C Bower3, Gregory A Nuttall4, Jeffrey W Britton5. 1. Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: Feyissa.Anteneh@mayo.edu. 2. Department of Cardiovascular Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: Pochettino.Alberto@mayo.edu. 3. Department of Vascular Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: bower.thomas@mayo.edu. 4. Department of Anesthesia, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: gnuttall@mayo.edu. 5. Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: britton.jeffrey@mayo.edu.
Abstract
OBJECTIVE: The main objective of this study is to examine the prevalence and timing of rhythmic electrographic discharges and periodic sharp transients during aortic arch repair surgeries using DHCA as detected by continuous intraoperative encephalogram (EEG) and correlate it with outcome. METHODS: Electronic medical records and the intraoperative EEGs of 32 patients who underwent aortic arch reconstruction with DHCA were reviewed. Preoperative patient characteristics, intraoperative data, and postoperative outcomes were examined. EEGs were graded based on the frequency of sharp transients (grade 0-2) and/or the presence of rhythmic electrographic discharges (grade 3). RESULTS: Periodic sharp transients were seen in 30/32 cases. Grade 1 and grade 2 activations were more prominent during cooling at nasopharyngeal temperature of 23.9±4.01 °C (mean±SDV). Rhythmic electrographic discharges occurred in seven patients and were exclusively seen during cooling at nasopharyngeal temperatures below 28 °C except in one case during rewarming at nasopharyngeal temperatures of 22°C. No patient with rhythmic discharges developed postoperative clinical neurologic deficit or seizures. CONCLUSIONS: Periodic sharp transients occurred in almost all cases during induction of deep hypothermia. This activity was not associated with postoperative neurologic deficit. SIGNIFICANCE: Clinical neurophysiologists, technicians and surgeons need to be aware that low amplitude periodic sharp transients and rhythmic electrographic discharges are common during DHCA, yet have no apparent clinical significance. Published by Elsevier Ireland Ltd.
OBJECTIVE: The main objective of this study is to examine the prevalence and timing of rhythmic electrographic discharges and periodic sharp transients during aortic arch repair surgeries using DHCA as detected by continuous intraoperative encephalogram (EEG) and correlate it with outcome. METHODS: Electronic medical records and the intraoperative EEGs of 32 patients who underwent aortic arch reconstruction with DHCA were reviewed. Preoperative patient characteristics, intraoperative data, and postoperative outcomes were examined. EEGs were graded based on the frequency of sharp transients (grade 0-2) and/or the presence of rhythmic electrographic discharges (grade 3). RESULTS: Periodic sharp transients were seen in 30/32 cases. Grade 1 and grade 2 activations were more prominent during cooling at nasopharyngeal temperature of 23.9±4.01 °C (mean±SDV). Rhythmic electrographic discharges occurred in seven patients and were exclusively seen during cooling at nasopharyngeal temperatures below 28 °C except in one case during rewarming at nasopharyngeal temperatures of 22°C. No patient with rhythmic discharges developed postoperative clinical neurologic deficit or seizures. CONCLUSIONS: Periodic sharp transients occurred in almost all cases during induction of deep hypothermia. This activity was not associated with postoperative neurologic deficit. SIGNIFICANCE: Clinical neurophysiologists, technicians and surgeons need to be aware that low amplitude periodic sharp transients and rhythmic electrographic discharges are common during DHCA, yet have no apparent clinical significance. Published by Elsevier Ireland Ltd.
Entities:
Keywords:
Aortic arch repair; Deep hypothermia; EEG; Intraoperative EEG monitoring; Rhythmic electrographic discharges; Sharp transients; Status epilepticus; Therapeutic hypothermia