BACKGROUND: Diabetes damages peripheral tissues; however, its effects on the lung are less known. Lung diffusing capacity (DLCO) is influenced by alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume (VC), both of which are reduced in adults with type 1 diabetes (T1D). OBJECTIVE: We sought to determine if diabetes duration affects DLCO, DM, VC, and cardiac output (Q). METHODS: 24 T1D patients (10.7-52.8 years) and 24 non-diabetic controls were recruited and had DLCO, DM, VC, and Q measured at rest and during exercise (40, 70 and 90% VO2max). RESULTS: When stratified into two groups based on age (young, <20.6 years old), there were no significant differences in DLCO, DM, VC, or Q (all of which were normalized to body surface area [BSA]) in the young group or in the old group. When stratified by diabetes duration (short duration, 0.33-8.9 years vs. long duration, 9.6-28 years), the T1D patients in the long duration group had lower DLCO/BSA and DM/BSA compared to the controls (p < 0.05). There were no differences in any of the variables in the short duration group. CONCLUSIONS: This study has shown that duration of diabetes is associated with decrements in diffusing capacity and its components.
BACKGROUND:Diabetes damages peripheral tissues; however, its effects on the lung are less known. Lung diffusing capacity (DLCO) is influenced by alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume (VC), both of which are reduced in adults with type 1 diabetes (T1D). OBJECTIVE: We sought to determine if diabetes duration affects DLCO, DM, VC, and cardiac output (Q). METHODS: 24 T1D patients (10.7-52.8 years) and 24 non-diabetic controls were recruited and had DLCO, DM, VC, and Q measured at rest and during exercise (40, 70 and 90% VO2max). RESULTS: When stratified into two groups based on age (young, <20.6 years old), there were no significant differences in DLCO, DM, VC, or Q (all of which were normalized to body surface area [BSA]) in the young group or in the old group. When stratified by diabetes duration (short duration, 0.33-8.9 years vs. long duration, 9.6-28 years), the T1D patients in the long duration group had lower DLCO/BSA and DM/BSA compared to the controls (p < 0.05). There were no differences in any of the variables in the short duration group. CONCLUSIONS: This study has shown that duration of diabetes is associated with decrements in diffusing capacity and its components.
Authors: M H Slaughter; T G Lohman; R A Boileau; C A Horswill; R J Stillman; M D Van Loan; D A Bemben Journal: Hum Biol Date: 1988-10 Impact factor: 0.553
Authors: F Innocenti; A Fabbri; R Anichini; S Tuci; G Pettinà; F Vannucci; L A De Giorgio; G Seghieri Journal: Diabetes Res Clin Pract Date: 1994-10 Impact factor: 5.602
Authors: Silmara Gusso; Teresa E Pinto; James C Baldi; Elizabeth Robinson; Wayne S Cutfield; Paul L Hofman Journal: Diabetes Care Date: 2012-07-06 Impact factor: 19.112