Literature DB >> 2675617

The nature of the lymphocytes surrounding Reed-Sternberg cells in nodular lymphocyte predominance and in other types of Hodgkin's disease.

S Poppema1.   

Abstract

The lymphocytes surrounding Reed-Sternberg cells may play an important role in the pathogenesis of Hodgkin's disease. In this study, T cells in different subtypes of Hodgkin's disease were analyzed in situ by an immunoperoxidase method employing a panel of antibodies, including several paraffin tissue-reactive monoclonal antibodies. The T cells in Hodgkin's disease-involved tissues were found to be activated CD4-positive T cells that are UCHL1+ and CD45R-. This immunophenotype is compatible with an activated helper-inducer memory T cell population. The T cells in the nodular lymphocyte predominance subtype were found to have additional positivity for Leu 7, indicating a subpopulation of CD4+ T cells, normally confined to the light zone of germinal centers of secondary follicles.

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Year:  1989        PMID： 2675617      PMCID： PMC1879922     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  22 in total

1.  Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma.

Authors:  W Timens; L Visser; S Poppema
Journal:  Lab Invest       Date:  1986-04       Impact factor: 5.662

2.  Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.

Authors:  H M Serra; J F Krowka; J A Ledbetter; L M Pilarski
Journal:  J Immunol       Date:  1988-03-01       Impact factor: 5.422

3.  Molecular pathways of adhesion in spontaneous rosetting of T-lymphocytes to the Hodgkin's cell line L428.

Authors:  M E Sanders; M W Makgoba; E H Sussman; G E Luce; J Cossman; S Shaw
Journal:  Cancer Res       Date:  1988-01-01       Impact factor: 12.701

4.  Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

Authors:  L A Greenbaum; J B Horowitz; A Woods; T Pasqualini; E P Reich; K Bottomly
Journal:  J Immunol       Date:  1988-03-01       Impact factor: 5.422

5.  Phenotypic diversity of the CD45 antigen and its relationship to function.

Authors:  P C Beverley; M Merkenschlager; L Terry
Journal:  Immunol Suppl       Date:  1988

6.  Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

Authors:  A N Akbar; L Terry; A Timms; P C Beverley; G Janossy
Journal:  J Immunol       Date:  1988-04-01       Impact factor: 5.422

7.  Immunohistochemical analysis of human lymphomas with monoclonal antibodies to B cell and Ia antigens reactive in paraffin sections.

Authors:  R J Marder; D Variakojis; J Silver; A L Epstein
Journal:  Lab Invest       Date:  1985-05       Impact factor: 5.662

8.  Two subsets of human CD4+ T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon-gamma can be defined by the Leu-18 and UCHL1 monoclonal antibodies.

Authors:  M Dohlsten; G Hedlund; H O Sjögren; R Carlsson
Journal:  Eur J Immunol       Date:  1988-08       Impact factor: 5.532

9.  Functional analysis of cloned germinal center CD4+ cells with natural killer cell-related features. Divergence from typical T helper cells.

Authors:  A Velardi; M C Mingari; L Moretta; C E Grossi
Journal:  J Immunol       Date:  1986-11-01       Impact factor: 5.422

10.  Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.

Authors:  M L Dustin; M E Sanders; S Shaw; T A Springer
Journal:  J Exp Med       Date:  1987-03-01       Impact factor: 14.307
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  19 in total

1.  High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltratein Hodgkin's lymphoma.

Authors:  A van den Berg; L Visser; S Poppema
Journal:  Am J Pathol       Date:  1999-06       Impact factor: 4.307

2.  Hodgkin's lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments.

Authors:  Cigdem Atayar; Anke van den Berg; Tjasso Blokzijl; Marcel Boot; Randy D Gascoyne; Lydia Visser; Sibrand Poppema
Journal:  J Clin Pathol       Date:  2006-12-08       Impact factor: 3.411

3.  Absence of HLA class I expression by Reed-Sternberg cells.

Authors:  S Poppema; L Visser
Journal:  Am J Pathol       Date:  1994-07       Impact factor: 4.307

4.  Lymphocyte-predominant Hodgkin's disease. An immunohistochemical analysis of 208 reviewed Hodgkin's disease cases from the German Hodgkin Study Group.

Authors:  R von Wasielewski; M Werner; R Fischer; M L Hansmann; K Hübner; D Hasenclever; J Franklin; M Sextro; V Diehl; A Georgii
Journal:  Am J Pathol       Date:  1997-03       Impact factor: 4.307

5.  CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease.

Authors:  A Carbone; A Gloghini; H J Gruss; A Pinto
Journal:  Am J Pathol       Date:  1995-10       Impact factor: 4.307

6.  Defining characteristics of classical Hodgkin lymphoma microenvironment T-helper cells.

Authors:  Paul Greaves; Andrew Clear; Andrew Owen; Sameena Iqbal; Abigail Lee; Janet Matthews; Andrew Wilson; Maria Calaminici; John G Gribben
Journal:  Blood       Date:  2013-09-04       Impact factor: 22.113

7.  Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion.

Authors:  Marie Fischer; Ilkka T Harvima; Ricardo F S Carvalho; Christine Möller; Anita Naukkarinen; Gunilla Enblad; Gunnar Nilsson
Journal:  J Clin Invest       Date:  2006-09-07       Impact factor: 14.808

8.  CD8(+) T cells in Hodgkin's disease tumor tissue are a polyclonal population with limited clonal expansion but little evidence of selection by antigen.

Authors:  K Willenbrock; A Roers; B Blöhbaum; K Rajewsky; M L Hansmann
Journal:  Am J Pathol       Date:  2000-07       Impact factor: 4.307

9.  T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications.

Authors:  Claudio Fozza; Maurizio Longinotti
Journal:  Adv Hematol       Date:  2010-10-12

10.  Hodgkin's Lymphomas: A Tumor Recognized by Its Microenvironment.

Authors:  S Montes-Moreno
Journal:  Adv Hematol       Date:  2010-10-24
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