Jakob Starup-Linde1, Simon Lykkeboe1, Søren Gregersen1, Ellen-Magrethe Hauge1, Bente Lomholt Langdahl1, Aase Handberg1, Peter Vestergaard1. 1. Departments of Endocrinology and Internal Medicine (J.S.-L., S.G., L.L.) and Rheumatology (E.-M.H.), Aarhus University Hospital, DK-8000 C Aarhus, Denmark; Department of Clinical Medicine (J.S.-L., A.H., P.V.), Aalborg University, DK-9220 Aalborg, Denmark; Departments of Clinical Biochemistry (S.L., A.H.) and Endocrinology (P.V.), Aalborg University Hospital, DK-9000 Aalborg, Denmark.
Abstract
CONTEXT: Type 1 and type 2 diabetes mellitus are associated with an increased risk of fracture. OBJECTIVE: The objective of the study was to compare the bone structure and density between type 1 and type 2 diabetes patients and to investigate fracture associations. DESIGN: This was a cross-sectional study. SETTING AND PATIENTS: Physician-diagnosed type 1 and type 2 diabetes patients were included from the outpatient clinics at two university hospitals participated in the study. MAIN OUTCOME MEASURES: Bone density and structure were assessed by dual-energy x-ray absorptiometry and high-resolution peripheral quantitative computed tomography. Blood samples were collected for bone turnover markers. Prevalent vertebral fractures were assessed by vertebral fracture assessment and x-ray, and incident fractures were collected from The Danish National Hospital Discharge Register. RESULTS: Bone mineral density (BMD) was higher in type 2 than type 1 diabetes patients at the hip, femur, and spine; however, only the hip differed in multivariate-adjusted models. Bone tissue stiffness at the tibia was increased in type 2 diabetes patients also in adjusted models. Sclerostin levels were inversely associated with fracture in type 1 diabetes patients. The patients with the highest tertile of sclerostin had an 81% decreased risk of a fracture compared with the lowest tertile. CONCLUSIONS: Type 1 and type 2 diabetes patients differ in BMD of the hip and tissue stiffness at the tibia. Sclerostin may be a marker independent of BMD to predict fractures in type 1 diabetes patients and thus potentially of clinical importance. Studies with longer follow-up are needed.
CONTEXT: Type 1 and type 2 diabetes mellitus are associated with an increased risk of fracture. OBJECTIVE: The objective of the study was to compare the bone structure and density between type 1 and type 2 diabetespatients and to investigate fracture associations. DESIGN: This was a cross-sectional study. SETTING AND PATIENTS: Physician-diagnosed type 1 and type 2 diabetespatients were included from the outpatient clinics at two university hospitals participated in the study. MAIN OUTCOME MEASURES: Bone density and structure were assessed by dual-energy x-ray absorptiometry and high-resolution peripheral quantitative computed tomography. Blood samples were collected for bone turnover markers. Prevalent vertebral fractures were assessed by vertebral fracture assessment and x-ray, and incident fractures were collected from The Danish National Hospital Discharge Register. RESULTS: Bone mineral density (BMD) was higher in type 2 than type 1 diabetespatients at the hip, femur, and spine; however, only the hip differed in multivariate-adjusted models. Bone tissue stiffness at the tibia was increased in type 2 diabetespatients also in adjusted models. Sclerostin levels were inversely associated with fracture in type 1 diabetespatients. The patients with the highest tertile of sclerostin had an 81% decreased risk of a fracture compared with the lowest tertile. CONCLUSIONS: Type 1 and type 2 diabetespatients differ in BMD of the hip and tissue stiffness at the tibia. Sclerostin may be a marker independent of BMD to predict fractures in type 1 diabetespatients and thus potentially of clinical importance. Studies with longer follow-up are needed.
Authors: Adriana Lelis Carvalho; Victoria E DeMambro; Anyonya R Guntur; Phuong Le; Kenichi Nagano; Roland Baron; Francisco José Albuquerque de Paula; Katherine J Motyl Journal: J Cell Physiol Date: 2017-08-04 Impact factor: 6.384