Literature DB >> 2675193

Serotonin and depression: old problems and new data.

A Plaznik1, W Kostowski, T Archer.   

Abstract

1. Several lines of evidence implicating some dysfunction or alteration to brain serotonergic systems in depressive states are summarized. 2. Some aspects of the interactions between the 5-HT and catecholamine pathways in the action of antidepressant drugs are examined. 3. Finally, the important role of NA modulation of serotonergic activity in the action of antidepressants is suggested.

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Year:  1989        PMID: 2675193     DOI: 10.1016/0278-5846(89)90050-x

Source DB:  PubMed          Journal:  Prog Neuropsychopharmacol Biol Psychiatry        ISSN: 0278-5846            Impact factor:   5.067


  4 in total

1.  A genetic rat model of depression, Flinders sensitive line, has a lower density of 5-HT(1A) receptors, but a higher density of 5-HT(1B) receptors, compared to control rats.

Authors:  Kyoko Nishi; Kazuya Kanemaru; Mirko Diksic
Journal:  Neurochem Int       Date:  2008-12-13       Impact factor: 3.921

2.  Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague-Dawley rats.

Authors:  Kazuya Kanemaru; Kyoko Nishi; Shu Hasegawa; Mirko Diksic
Journal:  Neurochem Int       Date:  2009 May-Jun       Impact factor: 3.921

3.  AGN-2979, an inhibitor of tryptophan hydroxylase activation, does not affect serotonin synthesis in Flinders Sensitive Line rats, a rat model of depression, but produces a significant effect in Flinders Resistant Line rats.

Authors:  Kazuya Kanemaru; Kyoko Nishi; Mirko Diksic
Journal:  Neurochem Int       Date:  2009-05-20       Impact factor: 3.921

Review 4.  Modulation of early stress-induced neurobiological changes: a review of behavioural and pharmacological interventions in animal models.

Authors:  E L Harrison; B T Baune
Journal:  Transl Psychiatry       Date:  2014-05-13       Impact factor: 6.222

  4 in total

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