Literature DB >> 2675139

Urocanic acid and immunosuppression.

M Norval, T J Simpson, J A Ross.   

Abstract

Urocanic acid, a molecule found at high concentration in the stratum corneum, acts as a photoreceptor for UV-light, isomerizing from the naturally occurring trans-form to the cis-form. It has been proposed that cis-urocanic acid may mediate the transient alteration in immune surveillance resulting in immunosuppression induced after UV-irradiation, by interacting with immune cells locally and/or systemically to generate T cells with suppressor function. The evidence to support this hypothesis is summarized, and possible interactions of urocanic acid with immune cells and their outcome are discussed.

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Year:  1989        PMID： 2675139     DOI： 10.1111/j.1751-1097.1989.tb04159.x

Source DB:  PubMed          Journal:  Photochem Photobiol        ISSN： 0031-8655            Impact factor:   3.421


  10 in total

1.  Urocanic acid as an efficient hydroxyl radical scavenger: a quantum theoretical study.

Authors:  Saumya Tiwari; Phool Chand Mishra
Journal:  J Mol Model       Date:  2010-04-02       Impact factor: 1.810

2.  Histamine involvement in UVB- and cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses.

Authors:  P H Hart; A Jaksic; G Swift; M Norval; A A el-Ghorr; J J Finlay-Jones
Journal:  Immunology       Date:  1997-08       Impact factor: 7.397

3.  Carnosine (beta-alanylhistidine) protects from the suppression of contact hypersensitivity by ultraviolet B (280-320 nm) radiation or by cis urocanic acid.

Authors:  V E Reeve; M Bosnic; E Rozinova
Journal:  Immunology       Date:  1993-01       Impact factor: 7.397

4.  The role of urocanic acid in UVB-induced suppression of immunity to Trichinella spiralis infection in the rat.

Authors:  J Garssen; M Norval; J Crosby; P Dortant; H Van Loveren
Journal:  Immunology       Date:  1999-02       Impact factor: 7.397

5.  Prevention of spontaneous and cyclophosphamide-induced diabetes in non-obese diabetic (NOD) mice with oral 2-acetyl-4-tetrahydroxybutylimidazole (THI), a component of caramel colouring III.

Authors:  T E Mandel; M Koulmanda; I R Mackay
Journal:  Clin Exp Immunol       Date:  1992-06       Impact factor: 4.330

6.  Fluorescent light activates the immunomodulator cis-urocanic acid in vitro: implications for patients with systemic lupus erythematosus.

Authors:  H McGrath; J M Bell; J W Haycock
Journal:  Ann Rheum Dis       Date:  1994-06       Impact factor: 19.103

7.  Treatment of contact hypersensitivity with urocanic acid.

Authors:  G A van Strien; M J Korstanje
Journal:  Arch Dermatol Res       Date:  1995       Impact factor: 3.017

Review 8.  Fernblock, a nutriceutical with photoprotective properties and potential preventive agent for skin photoaging and photoinduced skin cancers.

Authors:  Salvador Gonzalez; Yolanda Gilaberte; Neena Philips; Angeles Juarranz
Journal:  Int J Mol Sci       Date:  2011-11-29       Impact factor: 5.923

Review 9.  Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals.

Authors:  Ricardo Bosch; Neena Philips; Jorge A Suárez-Pérez; Angeles Juarranz; Avani Devmurari; Jovinna Chalensouk-Khaosaat; Salvador González
Journal:  Antioxidants (Basel)       Date:  2015-03-26

Review 10.  Non-Melanoma Skin Cancers: Biological and Clinical Features.

Authors:  Mauro Cives; Francesco Mannavola; Lucia Lospalluti; Maria Chiara Sergi; Gerardo Cazzato; Elisabetta Filoni; Federica Cavallo; Giuseppe Giudice; Luigia Stefania Stucci; Camillo Porta; Marco Tucci
Journal:  Int J Mol Sci       Date:  2020-07-29       Impact factor: 5.923
  10 in total

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