Literature DB >> 26751246

A dual role of Erk signaling in embryonic stem cells.

Xinwei Ma1, Haixia Chen1, Lingyi Chen2.   

Abstract

Erk signaling plays a critical role in maintaining the pluripotency of mouse embryonic stem cells (ESCs). Inhibition of Mek/Erk signaling by pharmacologic Mek inhibitor promotes self-renewal and pluripotency of mouse ESCs. However, knockout of Erk1/2 genes compromises the self-renewal and genomic stability of mouse ESCs. In this review, we summarize recent progress in understanding the role of Erk signaling in pluripotency maintenance, discuss the dual role of Erk in mouse ESCs, and provide explanations for the conflicting data regarding Mek inhibition and Erk knockout. Remaining questions and the prospects of Erk signaling in pluripotency maintenance are also discussed.
Copyright © 2016 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 26751246     DOI： 10.1016/j.exphem.2015.12.008

Source DB:  PubMed          Journal:  Exp Hematol        ISSN： 0301-472X            Impact factor:   3.084


  6 in total

1.  Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo.

Authors:  Michael J Pokrass; Kathleen A Ryan; Tianchi Xin; Brittany Pielstick; Winston Timp; Valentina Greco; Sergi Regot
Journal:  Dev Cell       Date:  2020-10-21       Impact factor: 12.270

2.  MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis.

Authors:  Carolyn Sangokoya; Robert Blelloch
Journal:  Proc Natl Acad Sci U S A       Date:  2020-08-11       Impact factor: 11.205

3.  A novel and promising therapeutic approach for NSCLC: recombinant human arginase alone or combined with autophagy inhibitor.

Authors:  Weitao Shen; Xuyao Zhang; Xiang Fu; Jiajun Fan; Jingyun Luan; Zhonglian Cao; Ping Yang; Zhongyuan Xu; Dianwen Ju
Journal:  Cell Death Dis       Date:  2017-03-30       Impact factor: 8.469

4.  Preserving self-renewal of porcine pluripotent stem cells in serum-free 3i culture condition and independent of LIF and b-FGF cytokines.

Authors:  Yangyang Ma; Tong Yu; Yuanxing Cai; Huayan Wang
Journal:  Cell Death Discov       Date:  2018-02-14

Review 5.  Protein Kinases and Their Inhibitors in Pluripotent Stem Cell Fate Regulation.

Authors:  Jungwoon Lee; Young-Jun Park; Haiyoung Jung
Journal:  Stem Cells Int       Date:  2019-07-24       Impact factor: 5.443

Review 6.  Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor.

Authors:  Hao Li; Peter Hohenstein; Satu Kuure
Journal:  Genes (Basel)       Date:  2021-02-23       Impact factor: 4.096
  6 in total

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