CONTEXT: Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats. OBJECTIVE: The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention in postmenopausal women. DESIGN: The study was a double-blind, placebo-controlled, randomized-order crossover design of 500 g hesperidin with or without 500 mg calcium supplement in 12 healthy postmenopausal women. Bone calcium retention was determined from urinary excretion of the rare isotope, (41)Ca, from bone. RESULTS: Calcium plus hesperidin, but not hesperidin alone, improved bone calcium retention by 5.5% (P < .04). CONCLUSION:Calcium supplementation (Calcilock), in combination with hesperidin, is effective at preserving bone in postmenopausal women.
RCT Entities:
CONTEXT: Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats. OBJECTIVE: The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention in postmenopausal women. DESIGN: The study was a double-blind, placebo-controlled, randomized-order crossover design of 500 g hesperidin with or without 500 mg calcium supplement in 12 healthy postmenopausal women. Bone calcium retention was determined from urinary excretion of the rare isotope, (41)Ca, from bone. RESULTS:Calcium plus hesperidin, but not hesperidin alone, improved bone calcium retention by 5.5% (P < .04). CONCLUSION:Calcium supplementation (Calcilock), in combination with hesperidin, is effective at preserving bone in postmenopausal women.
Authors: Athanasios C Pappas; Evangelos Zoidis; Michael Goliomytis; Panagiotis E Simitzis; Kyriaki Sotirakoglou; Maria A Charismiadou; Christos Nikitas; George Danezis; Stelios G Deligeorgis; Constantinos A Georgiou Journal: Antioxidants (Basel) Date: 2019-09-01
Authors: Evangelos Zoidis; Athanasios C Pappas; Michael Goliomytis; Panagiotis E Simitzis; Kyriaki Sotirakoglou; Savvina Tavrizelou; George Danezis; Constantinos A Georgiou Journal: Antioxidants (Basel) Date: 2021-01-09