| Literature DB >> 26750932 |
Yu G Motin1, A V Lepilov2, N P Bgatova3, A Yu Zharikov2, N V Motina2, G A Lapii4, E L Lushnikova4, L M Nepomnyashchikh4.
Abstract
Morphological and ultrastructural study of the kidney was performed in rats with oxalate nephrolithiasis. Specific features of endoplasmic reticulum stress were evaluated during nephrolithiasis and treatment with α-tocopherol. We observed the signs of endoplasmic reticulum stress with activation of proapoptotic pathways and injury to the cell lining in nephron tubules and collecting ducts. Ultrastructural changes were found in the organelles, nuclei, and cell membranes of epitheliocytes. A relationship was revealed between endoplasmic reticulum stress and oxidative damage, which developed at the early state of lithogenesis.Entities:
Keywords: endoplasmic reticulum stress; experimental nephrolithiasis; renal epithelium; ultrastructure; α-tocopherol
Mesh：
Substances：
Year: 2016 PMID： 26750932 DOI： 10.1007/s10517-016-3176-x
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804