| Literature DB >> 26750929 |
E V Shakhristova1, E A Stepovaya2, N V Ryazantseva3, O L Nosareva2, V D Yakushina2, V V Ivanov2, V V Novitskii2.
Abstract
MCF-7 breast cancer cells and HBL-100 breast epithelial cells were cultured with N-ethylmaleimide, a blocker of SH groups. Changes in redox potential of the glutathione system, activities of glutathione reductase, glutathione peroxidase, and intensity of apoptotic cell death were evaluated. The results indicate that incubation with N-ethylmaleimide led to glutathione system imbalance, reduced tumor cell redox potential, and induced their programmed death, which seemed useful for prospective target therapy of tumor diseases.Entities:
Keywords: apoptosis; breast adenocarcinoma; oxidative stress; redox regulation; tumor Progress
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Year: 2016 PMID： 26750929 DOI： 10.1007/s10517-016-3172-1
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804