OBJECTIVE: The present study investigated structural brain differences between adolescents with ADHD and matched control participants. METHOD: Voxel-based morphometry (VBM) using the DARTEL approach was performed to assess regional gray matter (GM) volumes. Additionally, individual performance on tests of attention was recorded to correlate ADHD related cognitive impairments with regional gray matter abnormalities. RESULTS: We found significantly smaller GM volume in subjects with ADHD compared to their matched controls within the anterior cingulate cortex (ACC), the occipital cortex, bilateral hippocampus/amygdala and in widespread cerebellar regions. Further, reductions of the ACC gray matter volume were found to correlate with scores of selective inattention. CONCLUSION: These findings underline that structural alterations in a widespread cortico-subcortical network seem to underlie the observable attention problems in patients with ADHD.
OBJECTIVE: The present study investigated structural brain differences between adolescents with ADHD and matched control participants. METHOD: Voxel-based morphometry (VBM) using the DARTEL approach was performed to assess regional gray matter (GM) volumes. Additionally, individual performance on tests of attention was recorded to correlate ADHD related cognitive impairments with regional gray matter abnormalities. RESULTS: We found significantly smaller GM volume in subjects with ADHD compared to their matched controls within the anterior cingulate cortex (ACC), the occipital cortex, bilateral hippocampus/amygdala and in widespread cerebellar regions. Further, reductions of the ACC gray matter volume were found to correlate with scores of selective inattention. CONCLUSION: These findings underline that structural alterations in a widespread cortico-subcortical network seem to underlie the observable attention problems in patients with ADHD.
Authors: Matthew D Albaugh; Catherine Orr; Bader Chaarani; Robert R Althoff; Nicholas Allgaier; Nicholas D'Alberto; Kelsey Hudson; Scott Mackey; Philip A Spechler; Tobias Banaschewski; Rüdiger Brühl; Arun L W Bokde; Uli Bromberg; Christian Büchel; Anna Cattrell; Patricia J Conrod; Sylvane Desrivières; Herta Flor; Vincent Frouin; Jürgen Gallinat; Robert Goodman; Penny Gowland; Yvonne Grimmer; Andreas Heinz; Viola Kappel; Jean-Luc Martinot; Marie-Laure Paillère Martinot; Frauke Nees; Dimitri Papadopoulos Orfanos; Jani Penttila; Luise Poustka; Tomáš Paus; Michael N Smolka; Maren Struve; Henrik Walter; Robert Whelan; Gunter Schumann; Hugh Garavan; Alexandra S Potter Journal: Biol Psychiatry Date: 2017-01-13 Impact factor: 13.382
Authors: Amy Krain Roy; Randi Bennett; Jonathan Posner; Leslie Hulvershorn; F Xavier Castellanos; Rachel G Klein Journal: Dev Psychopathol Date: 2017-08-14