Fenglai Xiao1, Dongmei An1, Du Lei1, Lei Li1, Sihan Chen1, Xintong Wu1, Tianhua Yang1, Jiechuan Ren1, Qiyong Gong2, Dong Zhou2. 1. From the Epilepsy Center, Department of Neurology (F.X., D.A., S.C., X.W., T.Y., J.R., D.Z.), and Huaxi MR Research Center, Department of Radiology (D.L., L.L., Q.G.), West China Hospital, Sichuan University, Chengdu, PR China. 2. From the Epilepsy Center, Department of Neurology (F.X., D.A., S.C., X.W., T.Y., J.R., D.Z.), and Huaxi MR Research Center, Department of Radiology (D.L., L.L., Q.G.), West China Hospital, Sichuan University, Chengdu, PR China. zhoudong66@yahoo.de qiyonggong@hmrrc.org.cn.
Abstract
OBJECTIVE: To identify the real-time effects of interictal rolandic spikes (or centrotemporal spikes [CTS]) on language, behavior, and cognitive function in patients with rolandic epilepsy (RE). METHODS: We studied 22 medication-naive patients with RE using EEG-fMRI with a 3T MRI scanner. We used simultaneous EEG to define the pre-CTS, CTS, and post-CTS periods. We analyzed the dynamic functional connectivity maps of the rolandic network during the 3 interictal CTS periods. RESULTS: The analysis of dynamic changes revealed positive correlations between the bilateral rolandic areas and the left inferior frontal gyrus (IFG; Broca area), the left inferior parietal lobe and the supramarginal gyrus (areas responsible for receptive language function), and the right IFG and left caudate. Anti-correlations were found in the default mode network (bilateral superior frontal gyrus, left middle frontal gyrus, left middle temporal gyrus, and right precuneus). CONCLUSIONS: Interictal CTS directly disrupts the functional brain networks responsible for language, behavior, and cognition in children with typical RE. It is important to suppress discharges to reduce the risk of neuropsychological impairments in children with RE.
OBJECTIVE: To identify the real-time effects of interictal rolandic spikes (or centrotemporal spikes [CTS]) on language, behavior, and cognitive function in patients with rolandic epilepsy (RE). METHODS: We studied 22 medication-naive patients with RE using EEG-fMRI with a 3T MRI scanner. We used simultaneous EEG to define the pre-CTS, CTS, and post-CTS periods. We analyzed the dynamic functional connectivity maps of the rolandic network during the 3 interictal CTS periods. RESULTS: The analysis of dynamic changes revealed positive correlations between the bilateral rolandic areas and the left inferior frontal gyrus (IFG; Broca area), the left inferior parietal lobe and the supramarginal gyrus (areas responsible for receptive language function), and the right IFG and left caudate. Anti-correlations were found in the default mode network (bilateral superior frontal gyrus, left middle frontal gyrus, left middle temporal gyrus, and right precuneus). CONCLUSIONS: Interictal CTS directly disrupts the functional brain networks responsible for language, behavior, and cognition in children with typical RE. It is important to suppress discharges to reduce the risk of neuropsychological impairments in children with RE.
Authors: Luigi Maccotta; Mayra A Lopez; Babatunde Adeyemo; Beau M Ances; Brian K Day; Lawrence N Eisenman; Joshua L Dowling; Eric C Leuthardt; Bradley L Schlaggar; Robert Edward Hogan Journal: Epilepsia Date: 2017-08-03 Impact factor: 5.864
Authors: Fiona M Baumer; Kristina Pfeifer; Adam Fogarty; Dalia Pena-Solorzano; Camarin E Rolle; Joanna L Wallace; Alexander Rotenberg; Robert S Fisher Journal: J Clin Neurophysiol Date: 2020-03 Impact factor: 2.590