Emilia Huvinen1, Nora Elisabeth Grotenfelt2, Johan Gunnar Eriksson2,3,4, Kristiina Rönö1, Miira Marjuska Klemetti1,5,6, Risto Roine7,8, Maritta Pöyhönen-Alho1, Aila Tiitinen1, Sture Andersson9, Hannele Laivuori1,6,10, Mikael Knip2,9,11,12, Anita Valkama2,4, Jelena Meinilä4, Hannu Kautiainen4,13, Beata Stach-Lempinen5, Saila Birgitta Koivusalo1. 1. a Department of Obstetrics and Gynecology , University of Helsinki and Helsinki University Hospital , Helsinki , Finland ; 2. b Folkhälsan Research Centre, Helsinki, University of Helsinki , Helsinki , Finland ; 3. c Department of Chronic Disease Prevention , National Institute for Health and Welfare , Helsinki , Finland ; 4. d Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital , Helsinki , Finland ; 5. e Department of Obstetrics and Gynecology , South-Karelia Central Hospital , Lappeenranta , Finland ; 6. f Medical Genetics, University of Helsinki and Helsinki University Hospital , Helsinki , Finland ; 7. g Department of Health and Social Management , University of Eastern Finland , Kuopio , Finland ; 8. h Group Administration, University of Helsinki and Helsinki University Hospital , Helsinki , Finland ; 9. j Children's Hospital, University of Helsinki and Helsinki University Hospital , Helsinki , Finland ; 10. i Institute for Molecular Medicine Finland , Helsinki , Finland ; 11. k Research Programs Unit, Diabetes and Obesity, University of Helsinki , Helsinki , Finland ; 12. l Tampere Centre for Child Health Research, Tampere University Hospital , Tampere , Finland ; 13. m Department of General Practice and Primary Health Care , University of Eastern Finland , Joensuu , Finland.
Abstract
OBJECTIVE: To study the incidence of gestational diabetes mellitus (GDM) in relation to phenotypic characteristics and gestational weight gain (GWG) among women at high risk for GDM. MATERIALS AND METHODS: This is a secondary analysis of a GDM prevention study (RADIEL), a randomized controlled trial conducted in Finland. 269 women with a history of GDM and/or a pre-pregnancy body mass index (BMI) ≥ 30 kg/m(2) were enrolled before 20 weeks of gestation and divided into four groups according to parity, BMI and previous history of GDM. The main outcome was incidence of GDM. RESULTS: There was a significant difference in incidence of GDM between the groups (p < 0.001). Women with a history of GDM and BMI <30 kg/m(2) showed the highest incidence (35.9%). At baseline they had fewer metabolic risk factors and by the second trimester they gained more weight. There was no interaction between GWG and GDM outcome and no significant difference in the prevalence of diabetes-associated antibodies. CONCLUSION: Despite a healthier metabolic profile at baseline the non-obese women with a history of GDM displayed a markedly higher cumulative incidence of GDM. GWG and the presence of diabetes-associated antibodies were not associated with GDM occurrence among these high-risk women. Key message Despite a healthier metabolic profile at baseline the non-obese women with previous gestational diabetes mellitus display a markedly higher cumulative incidence of gestational diabetes mellitus.
RCT Entities:
OBJECTIVE: To study the incidence of gestational diabetes mellitus (GDM) in relation to phenotypic characteristics and gestational weight gain (GWG) among women at high risk for GDM. MATERIALS AND METHODS: This is a secondary analysis of a GDM prevention study (RADIEL), a randomized controlled trial conducted in Finland. 269 women with a history of GDM and/or a pre-pregnancy body mass index (BMI) ≥ 30 kg/m(2) were enrolled before 20 weeks of gestation and divided into four groups according to parity, BMI and previous history of GDM. The main outcome was incidence of GDM. RESULTS: There was a significant difference in incidence of GDM between the groups (p < 0.001). Women with a history of GDM and BMI <30 kg/m(2) showed the highest incidence (35.9%). At baseline they had fewer metabolic risk factors and by the second trimester they gained more weight. There was no interaction between GWG and GDM outcome and no significant difference in the prevalence of diabetes-associated antibodies. CONCLUSION: Despite a healthier metabolic profile at baseline the non-obesewomen with a history of GDM displayed a markedly higher cumulative incidence of GDM. GWG and the presence of diabetes-associated antibodies were not associated with GDM occurrence among these high-risk women. Key message Despite a healthier metabolic profile at baseline the non-obesewomen with previous gestational diabetes mellitus display a markedly higher cumulative incidence of gestational diabetes mellitus.
Authors: Kristiina Rönö; Beata Stach-Lempinen; Johan Gunnar Eriksson; Maritta Pöyhönen-Alho; Miira Marjuska Klemetti; Risto Paavo Roine; Emilia Huvinen; Sture Andersson; Hannele Laivuori; Anita Valkama; Jelena Meinilä; Hannu Kautiainen; Aila Tiitinen; Saila Birgitta Koivusalo Journal: Int J Womens Health Date: 2018-08-27
Authors: Ning Wang; Yanqi Peng; Lu Wang; Lin Song; Bo Sun; Junxiang Wei; Ting Wang; Yang Mi; Wei Cui Journal: Diabetes Metab Syndr Obes Date: 2021-03-02 Impact factor: 3.168