Mark G Sucher1, Mauro Giordani1, Andrew Figoni2, Alexander J Nedopil3. 1. Department of Orthopaedics, University of California, Davis 4860 Y Street, Suite 3800, Sacramento, California, 95817, USA. 2. School of Medicine, University of California, Davis Education Building, 4610 X Street, Sacramento, California, 95817, USA. 3. Department of Orthopaedics, University of California, Davis 4860 Y Street, Suite 3800, Sacramento, California, 95817, USA. nedopil@mytum.de.
Abstract
PURPOSE: To evaluate the peri-operative blood loss with the use of epsilon-aminocaproic acid (ε-ACA) in total hip arthroplasty (THA). METHODS: One hundred sixty patients treated with THA were followed; 5 g ε-ACA diluted in 100 ml normal saline was applied intra-operatively. Eighty patients not receiving ε-ACA (non ε-ACA group) and eighty patients receiving ε-ACA (ε-ACA group) were compared regarding blood loss, need of transfusion, and thrombo-embolic complications. RESULTS: Blood loss (mean ± SD) for the non ε-ACA group was 1678 ± 515 ml and for the ε-ACA group 1403 ± 417 ml (p < 0.05). In the non ε-ACA group 23 patients needed blood transfusions compared to ten patients in the ε-ACA group (p < 0.05). Cost savings were $284.39 per patient. No patient in either group developed a thrombo-embolic complication. CONCLUSIONS: This study demonstrates a significant reduction in peri-operative blood loss after THA with topically applied ε-ACA. The application of ε-ACA reduced costs by lowering transfusion rates and did not increase thrombo-embolic events. ε-ACA is safe and effective in reducing blood loss and cost-efficient in THA.
PURPOSE: To evaluate the peri-operative blood loss with the use of epsilon-aminocaproic acid (ε-ACA) in total hip arthroplasty (THA). METHODS: One hundred sixty patients treated with THA were followed; 5 g ε-ACA diluted in 100 ml normal saline was applied intra-operatively. Eighty patients not receiving ε-ACA (non ε-ACA group) and eighty patients receiving ε-ACA (ε-ACA group) were compared regarding blood loss, need of transfusion, and thrombo-embolic complications. RESULTS:Blood loss (mean ± SD) for the non ε-ACA group was 1678 ± 515 ml and for the ε-ACA group 1403 ± 417 ml (p < 0.05). In the non ε-ACA group 23 patients needed blood transfusions compared to ten patients in the ε-ACA group (p < 0.05). Cost savings were $284.39 per patient. No patient in either group developed a thrombo-embolic complication. CONCLUSIONS: This study demonstrates a significant reduction in peri-operative blood loss after THA with topically applied ε-ACA. The application of ε-ACA reduced costs by lowering transfusion rates and did not increase thrombo-embolic events. ε-ACA is safe and effective in reducing blood loss and cost-efficient in THA.
Entities:
Keywords:
Blood loss; Epsilon-aminocaproic acid; Total hip arthroplasty
Authors: Klaus Martin; Jürgen Knorr; Tamás Breuer; Ralph Gertler; Martin Macguill; Rüdiger Lange; Peter Tassani; Gunther Wiesner Journal: J Cardiothorac Vasc Anesth Date: 2011-02 Impact factor: 2.628