| Literature DB >> 26743604 |
Fusheng Zhou1, Wenjun Wang2, Changbing Shen2, Hui Li2, Xianbo Zuo2, Xiaodong Zheng2, Min Yue2, Cuicui Zhang2, Liang Yu2, Mengyun Chen2, Caihong Zhu2, Xianyong Yin2, Mingjun Tang2, Yongjiang Li2, Gang Chen2, Zaixing Wang2, Shengxiu Liu2, Yi Zhou2, Fengyu Zhang3, Weijia Zhang4, Caihua Li5, Sen Yang6, Liangdan Sun7, Xuejun Zhang8.
Abstract
Psoriasis is a chronic hyperproliferative and inflammatory skin disease caused by the interplay of genetic and environmental factors. DNA methylation has been linked to psoriasis, but the manner in which this process contributes to the disease is not fully understood. In this study, we carried out a three-stage epigenome-wide association study to identify disease-associated differentially methylated sites using a combination of 262 skin and 48 peripheral blood mononuclear cell samples. We not only revealed genome-wide methylation patterns for psoriasis but also identified strong associations between the skin-specific DNA methylation of nine disease-associated differentially methylated sites and psoriasis (Wilcoxon ranked PBonferroni < 0.01; methylation level difference > 0.10). Further analysis revealed that these nine disease-associated differentially methylated sites were not significantly affected by genetic variations, supporting their remarkable contributions to disease status. The expression of CYP2S1, ECE1, EIF2C2, MAN1C1, and DLGAP4 was negatively correlated with DNA methylation. These findings will help us to better understand the molecular mechanism of psoriasis.Entities:
Mesh：
Substances：
Year: 2015 PMID： 26743604 DOI： 10.1016/j.jid.2015.12.029
Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551