Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 [Experimental models of human skin aging].

Literature DB >> 26743051

[Experimental models of human skin aging].

G Nikolakis^1,2, C Zoschke³, E Makrantonaki^1,4, C Hausmann³, M Schäfer-Korting³, C C Zouboulis^5,6.

Abstract

The skin is a representative model for the study of human aging. Despite the high regenerative capacity of the skin, skin physiology changes over the course of life. Medical and cosmetic research is trying to prevent aging, to slow, to stop, or to reverse it. Effects of age-related DNA damage and of changing skin structure on pharmacological parameters are largely unknown. This review article summarizes the state of scientific knowledge in the field of experimental models of human skin aging and shows approaches to improve organotypic skin models, to develop predictive models of aging, and improve aging research.

Entities: Species

Keywords: DNA damage; Drugs; Models, animal; Organotypic skin models; Skin physiology

Mesh：

Year: 2016 PMID： 26743051 DOI： 10.1007/s00105-015-3747-1

Source DB: PubMed Journal: Hautarzt ISSN： 0017-8470 Impact factor: 0.751

Keyword Cloud
References

45 in total

1. Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95).

Authors: C C Zouboulis; H Seltmann; H Neitzel; C E Orfanos
Journal: J Invest Dermatol Date: 1999-12 Impact factor: 8.551

Review 2. A review of ageing and an examination of clinical methods in the assessment of ageing skin. Part 2: Clinical perspectives and clinical methods in the evaluation of ageing skin.

Authors: T M Callaghan; K-P Wilhelm
Journal: Int J Cosmet Sci Date: 2008-10 Impact factor: 2.970

3. In vitro glycation of an endothelialized and innervated tissue-engineered skin to screen anti-AGE molecules.

Authors: Sébastien Cadau; Sabrina Leoty-Okombi; Sabine Pain; Nicolas Bechetoille; Valérie André-Frei; François Berthod
Journal: Biomaterials Date: 2015-02-19 Impact factor: 12.479

4. Effects of serially passaged fibroblasts on dermal and epidermal morphogenesis in human skin equivalents.

Authors: David Janson; Marion Rietveld; Rein Willemze; Abdoelwaheb El Ghalbzouri
Journal: Biogerontology Date: 2013-03-16 Impact factor: 4.277

5. Electrical properties of human skin as aging biomarkers.

Authors: Jovana B Simić-Krstić; Aleksandar J Kalauzi; Srdjan N Ribar; Lidija R Matija; Gradimir N Misevic
Journal: Exp Gerontol Date: 2014-06-03 Impact factor: 4.032

Review 6. Age and skin structure and function, a quantitative approach (II): protein, glycosaminoglycan, water, and lipid content and structure.

Authors: Jeanette M Waller; Howard I Maibach
Journal: Skin Res Technol Date: 2006-08 Impact factor: 2.365

[Experimental models of human skin aging].

1. Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95).

Review 2. A review of ageing and an examination of clinical methods in the assessment of ageing skin. Part 2: Clinical perspectives and clinical methods in the evaluation of ageing skin.

3. In vitro glycation of an endothelialized and innervated tissue-engineered skin to screen anti-AGE molecules.

4. Effects of serially passaged fibroblasts on dermal and epidermal morphogenesis in human skin equivalents.

5. Electrical properties of human skin as aging biomarkers.

Review 6. Age and skin structure and function, a quantitative approach (II): protein, glycosaminoglycan, water, and lipid content and structure.

7. A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

8. Stem cell depletion in Hutchinson-Gilford progeria syndrome.

Review 9. Age-induced hair greying - the multiple effects of oxidative stress.

10. Androgen receptor accelerates premature senescence of human dermal papilla cells in association with DNA damage.