| Literature DB >> 26742629 |
Pranab Ghosh1, Ashim Ghosh2, Amitava Mandal2, Sirin Salma Sultana3, Somaditya Dey3, Chiranjib Pal3.
Abstract
Oxygenated sterols (2-16) were synthesized by skeletal rearrangement of steroidal allylic alcohols. All the derivatives were screened for their anti-leishmanial activities. Compounds 3, 11 and 12 showed potent activities. Compound 12 was found least toxic and induced highest nitric oxide (NO) at 48 h. Least toxicity of compound 12 on splenocytes validated its best anti-amastigote effect and induction of NO.Entities:
Keywords: A-nor-cholest-6-hydroxy-5,7-olide; Anti-leishmanial activities; Cytotoxicity; Oxygenated sterols
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Year: 2015 PMID： 26742629 DOI： 10.1016/j.steroids.2015.12.020
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668