| Literature DB >> 2674210 |
M I Rendon1, P D Cruz, R D Sontheimer, P R Bergstresser.
Abstract
Tissue resistance to insulin is a major feature underlying the development of acanthosis nigricans in many patients. We report two unusual cases of acanthosis nigricans with contrasting forms of insulin resistance and propose an algorithm for the evaluation of patients with acanthosis nigricans. Further, we present a schematic framework that emphasizes the role of insulin and insulin growth factors in the pathogenesis of acanthosis nigricans.Entities:
Mesh：
Substances：
Year: 1989 PMID： 2674210 DOI： 10.1016/s0190-9622(89)70208-5
Source DB: PubMed Journal: J Am Acad Dermatol ISSN： 0190-9622 Impact factor: 11.527