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Literature DB >> 26739777

Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems.

Gautier M A Ndong Ntoutoume¹, Robert Granet¹, Jean Pierre Mbakidi¹, Frédérique Brégier¹, David Y Léger¹, Chloë Fidanzi-Dugas¹, Vincent Lequart², Nicolas Joly², Bertrand Liagre¹, Vincent Chaleix¹, Vincent Sol³.

Abstract

The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.

Entities: Chemical Disease Species

Keywords: Cancer cells; Cellulose nanocrystals; Curcumin; Drug delivery; Nanoparticles

Mesh：

Substances：

Year: 2015 PMID： 26739777 DOI： 10.1016/j.bmcl.2015.12.060

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

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