June Y Y Leung1, Hugh S Lam2, Gabriel M Leung1, C Mary Schooling1,3. 1. School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. 2. Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. 3. School of Public Health and Hunter College, City University of New York, New York.
Abstract
BACKGROUND: Preterm birth, early term birth, and low birthweight are associated with childhood wheezing disorders in developed Western settings, but observed associations could be confounded by socio-economic position. This study aims to clarify such associations in a developed non-Western setting with a different confounding structure. METHODS: Using Cox regression, we examined the adjusted associations of gestational age and birthweight for gestational age with time to first public hospital admission for asthma, bronchitis, and bronchiolitis (International Classification of Diseases, Ninth Version Clinical Modification 466, 490, and 493) from 9 days to 12 years in a population-representative birth cohort of 8327 Chinese children in Hong Kong, a developed setting with less clear social patterning of prematurity or birthweight. Analyses were adjusted for infant and parental characteristics and socio-economic position. RESULTS: Children born late preterm (34 to <37 weeks) had higher risk of hospitalisation for asthma and other wheezing disorders [hazard ratio (HR) 1.99, 95% confidence interval (CI) 1.48, 2.67] than children born full term (39 to <41 weeks). Early term births (37 to <39 weeks) had HR 1.01 (95% CI 0.84, 1.22), late term births (41 to <42 weeks) had HR 0.77 (95% 0.59, 1.01), and post-term births (≥42 weeks) had HR 0.56 (95% CI 0.32, 0.98). Large for gestational age was associated with lower risk of hospitalisation (HR 0.76, 95% CI 0.57, 0.99). CONCLUSION: The association of preterm birth with childhood wheezing could be biologically mediated. We cannot rule out an association for early term births.
BACKGROUND: Preterm birth, early term birth, and low birthweight are associated with childhood wheezing disorders in developed Western settings, but observed associations could be confounded by socio-economic position. This study aims to clarify such associations in a developed non-Western setting with a different confounding structure. METHODS: Using Cox regression, we examined the adjusted associations of gestational age and birthweight for gestational age with time to first public hospital admission for asthma, bronchitis, and bronchiolitis (International Classification of Diseases, Ninth Version Clinical Modification 466, 490, and 493) from 9 days to 12 years in a population-representative birth cohort of 8327 Chinese children in Hong Kong, a developed setting with less clear social patterning of prematurity or birthweight. Analyses were adjusted for infant and parental characteristics and socio-economic position. RESULTS:Children born late preterm (34 to <37 weeks) had higher risk of hospitalisation for asthma and other wheezing disorders [hazard ratio (HR) 1.99, 95% confidence interval (CI) 1.48, 2.67] than children born full term (39 to <41 weeks). Early term births (37 to <39 weeks) had HR 1.01 (95% CI 0.84, 1.22), late term births (41 to <42 weeks) had HR 0.77 (95% 0.59, 1.01), and post-term births (≥42 weeks) had HR 0.56 (95% CI 0.32, 0.98). Large for gestational age was associated with lower risk of hospitalisation (HR 0.76, 95% CI 0.57, 0.99). CONCLUSION: The association of preterm birth with childhood wheezing could be biologically mediated. We cannot rule out an association for early term births.
Authors: Marco Zaffanello; Giuliana Ferrante; Salvatore Fasola; Michele Piazza; Giorgio Piacentini; Stefania La Grutta Journal: Int J Environ Res Public Health Date: 2021-01-17 Impact factor: 3.390
Authors: Baoting He; Man Ki Kwok; Shiu Lun Au Yeung; Shi Lin Lin; June Yue Yan Leung; Lai Ling Hui; Albert M Li; Gabriel M Leung; C Mary Schooling Journal: Sci Rep Date: 2020-01-15 Impact factor: 4.379
Authors: Simon Kebede Merid; Alexei Novoloaca; Gemma C Sharp; Leanne K Küpers; Alvin T Kho; Ritu Roy; Lu Gao; Isabella Annesi-Maesano; Pooja Jain; Michelle Plusquin; Manolis Kogevinas; Catherine Allard; Florianne O Vehmeijer; Nabila Kazmi; Lucas A Salas; Faisal I Rezwan; Hongmei Zhang; Sylvain Sebert; Darina Czamara; Sheryl L Rifas-Shiman; Phillip E Melton; Debbie A Lawlor; Göran Pershagen; Carrie V Breton; Karen Huen; Nour Baiz; Luigi Gagliardi; Tim S Nawrot; Eva Corpeleijn; Patrice Perron; Liesbeth Duijts; Ellen Aagaard Nohr; Mariona Bustamante; Susan L Ewart; Wilfried Karmaus; Shanshan Zhao; Christian M Page; Zdenko Herceg; Marjo-Riitta Jarvelin; Jari Lahti; Andrea A Baccarelli; Denise Anderson; Priyadarshini Kachroo; Caroline L Relton; Anna Bergström; Brenda Eskenazi; Munawar Hussain Soomro; Paolo Vineis; Harold Snieder; Luigi Bouchard; Vincent W Jaddoe; Thorkild I A Sørensen; Martine Vrijheid; S Hasan Arshad; John W Holloway; Siri E Håberg; Per Magnus; Terence Dwyer; Elisabeth B Binder; Dawn L DeMeo; Judith M Vonk; John Newnham; Kelan G Tantisira; Inger Kull; Joseph L Wiemels; Barbara Heude; Jordi Sunyer; Wenche Nystad; Monica C Munthe-Kaas; Katri Räikkönen; Emily Oken; Rae-Chi Huang; Scott T Weiss; Josep Maria Antó; Jean Bousquet; Ashish Kumar; Cilla Söderhäll; Catarina Almqvist; Andres Cardenas; Olena Gruzieva; Cheng-Jian Xu; Sarah E Reese; Juha Kere; Petter Brodin; Olivia Solomon; Matthias Wielscher; Nina Holland; Akram Ghantous; Marie-France Hivert; Janine F Felix; Gerard H Koppelman; Stephanie J London; Erik Melén Journal: Genome Med Date: 2020-03-02 Impact factor: 11.117