Antonio Simone Laganà1, Onofrio Triolo2, Francesca Maria Salmeri3, Roberta Granese2, Vittorio Italo Palmara2, Helena Ban Frangež4, Eda Vrtčnik Bokal4, Vincenza Sofo3. 1. Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Via C. Valeria 1, 98125, Messina, Italy. antlagana@unime.it. 2. Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Via C. Valeria 1, 98125, Messina, Italy. 3. Department of Biomedical Sciences, Dentistry and Morphological and Functional Imaging, University of Messina, Via C. Valeria 1, 98125, Messina, Italy. 4. Department of Reproduction, University Medical Center Ljubljana, Slajmerjeva 3, 1000, Ljubljana, Slovenia.
Abstract
PURPOSE: Invariant Natural Killer T cells (iNKT) are a specialized subset of T cells that use their T cell receptor to recognize self and foreign lipids presented by CD1d as cognate antigens. iNKT have been shown to have either protective or harmful roles in many pathological states, including microbial infection, autoimmune disease, allergic disease and cancer. Accumulating evidence seems to suggest that this unique T cell subset combines both classically innate and adaptive immunologic characteristic. Considering these recent data, the aim of work was to review the current knowledge about iNKT in eutopic and ectopic endometrium. METHODS: Narrative overview, synthesizing the findings of literature retrieved from searches of computerized databases. RESULTS: Currently, the immune paradigm of reproduction is gradually changing shape: recent data confirmed that cytokine milieu influences the development and plasticity of different subtype of mononuclear cells, and in turn it can be influenced by the cytokine production of the latter. Among the different NKT cell populations, the recently characterized iNKT seems to share actions typical both of innate and adaptive immunity, being capable of secreting Th1 as well as Th2 cytokine pattern. Moreover, several subtypes of iNKT were identified, who partially express the same master transcription factors of the corresponding T cells counterpart. CONCLUSIONS: Although the data about iNKT's actions in eutopic and ectopic endometrium are still scarce, it is possible to hypothesize that future investigation can shed light on this point, thus allowing a better knowledge about the regulation of these two microenvironments.
PURPOSE: Invariant Natural Killer T cells (iNKT) are a specialized subset of T cells that use their T cell receptor to recognize self and foreign lipids presented by CD1d as cognate antigens. iNKT have been shown to have either protective or harmful roles in many pathological states, including microbial infection, autoimmune disease, allergic disease and cancer. Accumulating evidence seems to suggest that this unique T cell subset combines both classically innate and adaptive immunologic characteristic. Considering these recent data, the aim of work was to review the current knowledge about iNKT in eutopic and ectopic endometrium. METHODS: Narrative overview, synthesizing the findings of literature retrieved from searches of computerized databases. RESULTS: Currently, the immune paradigm of reproduction is gradually changing shape: recent data confirmed that cytokine milieu influences the development and plasticity of different subtype of mononuclear cells, and in turn it can be influenced by the cytokine production of the latter. Among the different NKT cell populations, the recently characterized iNKT seems to share actions typical both of innate and adaptive immunity, being capable of secreting Th1 as well as Th2 cytokine pattern. Moreover, several subtypes of iNKT were identified, who partially express the same master transcription factors of the corresponding T cells counterpart. CONCLUSIONS: Although the data about iNKT's actions in eutopic and ectopic endometrium are still scarce, it is possible to hypothesize that future investigation can shed light on this point, thus allowing a better knowledge about the regulation of these two microenvironments.
Entities:
Keywords:
Endometriosis; Endometrium; Immunity; Invariant natural killer T cells
Authors: Frederico J S Correa; Marina Paula Andres; Tainá Pezzin Rocha; Ana Eduarda Z Carvalho; Thiago P A Aloia; Marcus V N Corpa; Esper G Kallas; Cristóvão L P Mangueira; Edmund C Baracat; Karina I Carvalho; Mauricio S Abrão Journal: Clinics (Sao Paulo) Date: 2022-05-13 Impact factor: 2.898
Authors: Antonio Simone Laganà; Salvatore Giovanni Vitale; Maria Antonietta Trovato; Vittorio Italo Palmara; Agnese Maria Chiara Rapisarda; Roberta Granese; Emanuele Sturlese; Rosanna De Dominici; Stefano Alecci; Francesco Padula; Benito Chiofalo; Roberta Grasso; Pietro Cignini; Paolo D'Amico; Onofrio Triolo Journal: Biomed Res Int Date: 2016-08-04 Impact factor: 3.411