Literature DB >> 26739058

A Recombinant Adenovirus Expressing Ovine Interferon Tau Prevents Influenza Virus-Induced Lethality in Mice.

V Martín1, E Pascual2, M Avia2, G Rangel2, A de Molina3, A Alejo2, N Sevilla2.   

Abstract

Ovine interferon tau (IFN-τ) is a unique type I interferon with low toxicity and a broad host range in vivo. We report the generation of a nonreplicative recombinant adenovirus expressing biologically active IFN-τ. Using the B6.A2G-Mx1 mouse model, we showed that single-dose intranasal administration of recombinant Ad5-IFN-τ can effectively prevent lethality and disease induced by highly virulent hv-PR8 influenza virus by activating the interferon response and preventing viral replication.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 26739058      PMCID： PMC4794696          DOI： 10.1128/JVI.03258-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

Review 1.  Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors.

Authors:  Kenya Honda; Akinori Takaoka; Tadatsugu Taniguchi
Journal:  Immunity       Date:  2006-09       Impact factor: 31.745

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Authors:  S W Klemann; K Imakawa; R M Roberts
Journal:  Nucleic Acids Res       Date:  1990-11-25       Impact factor: 16.971

Review 3.  IFN-tau: a novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities.

Authors:  J L Martal; N M Chêne; L P Huynh; R M L'Haridon; P B Reinaud; M W Guillomot; M A Charlier; S Y Charpigny
Journal:  Biochimie       Date:  1998 Aug-Sep       Impact factor: 4.079

4.  CD4 T suppressor cells mediate interferon tau protection against experimental allergic encephalomyelitis.

Authors:  M G Mujtaba; J M Soos; H M Johnson
Journal:  J Neuroimmunol       Date:  1997-05       Impact factor: 3.478

5.  A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis.

Authors:  S D Der; Y L Yang; C Weissmann; B R Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

6.  Potent anti-feline immunodeficiency virus and anti-human immunodeficiency virus effect of IFN-tau.

Authors:  C H Pontzer; J K Yamamoto; F W Bazer; T L Ott; H M Johnson
Journal:  J Immunol       Date:  1997-05-01       Impact factor: 5.422

7.  In vitro and in vivo effects of recombinant bovine interferon-tau on bovine leukemia virus.

Authors:  Junko Kohara; Yuichi Yokomizo
Journal:  J Vet Med Sci       Date:  2007-01       Impact factor: 1.267

Review 8.  Placental interferons.

Authors:  F W Bazer; T E Spencer; T L Ott
Journal:  Am J Reprod Immunol       Date:  1996-04       Impact factor: 3.886

9.  Differential recognition of the type I interferon receptor by interferons tau and alpha is responsible for their disparate cytotoxicities.

Authors:  P S Subramaniam; S A Khan; C H Pontzer; H M Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-19       Impact factor: 11.205

10.  Functional role of type I and type II interferons in antiviral defense.

Authors:  U Müller; U Steinhoff; L F Reis; S Hemmi; J Pavlovic; R M Zinkernagel; M Aguet
Journal:  Science       Date:  1994-06-24       Impact factor: 47.728
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  3 in total

1.  Virus-induced autophagic degradation of STAT2 as a mechanism for interferon signaling blockade.

Authors:  Miguel Avia; José M Rojas; Lisa Miorin; Elena Pascual; Piet A Van Rijn; Verónica Martín; Adolfo García-Sastre; Noemí Sevilla
Journal:  EMBO Rep       Date:  2019-10-11       Impact factor: 8.807

2.  Temporal Dynamics of the Ruminant Type I IFN-Induced Antiviral State against Homologous Parainfluenza Virus 3 Challenge In Vitro.

Authors:  Min Sun; Fei Hao; Wenliang Li; Zilong Cheng; Wenwen Zhang; Leilei Yang; Li Mao; Maojun Liu
Journal:  Viruses       Date:  2022-05-11       Impact factor: 5.818

3.  Construction, expression and antiviral activity analysis of recombinant adenovirus expressing human IFITM3 in vitro.

Authors:  Shouwen Du; Yinyue Jiang; Wang Xu; Jieying Bai; Mingyao Tian; Maopeng Wang; Yuhang Wang; Tingting Cao; Lina Song; Yuhang Jiang; Jing Chen; Tingting Fu; Penfeng Hao; Tiyuan Li; Shipin Wu; Linzhu Ren; Ningyi Jin; Chang Li
Journal:  Int J Biol Macromol       Date:  2019-03-23       Impact factor: 6.953
  3 in total

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