Anders Vangkilde1, Line Olsen2, Louise K Hoeffding1, Carsten B Pedersen3, Preben B Mortensen4, Thomas Werge5, Betina Trabjerg4. 1. Mental Health Services Copenhagen, Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen, Denmark; Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark; 2. Mental Health Services Copenhagen, Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen, Denmark; Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark; line.olsen@regionh.dk. 3. Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark; National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark; Centre for Integrated Register-based Research, CIRRAU, Aarhus University, Aarhus, Denmark; 4. Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark; National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark; 5. Mental Health Services Copenhagen, Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen, Denmark; Initiative for Integrative Psychiatric Research, iPSYCH, The Lundbeck Foundation, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Abstract
OBJECTIVE: Cross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22q11.2 deletion syndrome. METHODS: Danish nationwide registers were linked to establish a cohort consisting of all Danish citizens born during 1955-2004 and the cohort was followed from January 1, 1994 until December 31, 2013. Data were analyzed using survival analyses and adjusted for calendar year, age, sex, and parental mental health history. RESULTS: A total of 156 individuals with 22q11.2 deletion syndrome were identified, out of which 6 individuals were diagnosed with schizophrenia spectrum disorders following identification with 22q11 deletion syndrome. Identified carriers of 22q11.2 deletion had an 8.13(95% CI: 3.65-18.09) fold increased risk of schizophrenia spectrum disorder. CONCLUSIONS: Carriers of a 22q11.2 deletion who had been clinically identified had a highly increased risk of schizophrenia spectrum disorders.
OBJECTIVE: Cross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22q11.2 deletion syndrome. METHODS: Danish nationwide registers were linked to establish a cohort consisting of all Danish citizens born during 1955-2004 and the cohort was followed from January 1, 1994 until December 31, 2013. Data were analyzed using survival analyses and adjusted for calendar year, age, sex, and parental mental health history. RESULTS: A total of 156 individuals with 22q11.2 deletion syndrome were identified, out of which 6 individuals were diagnosed with schizophrenia spectrum disorders following identification with 22q11 deletion syndrome. Identified carriers of 22q11.2 deletion had an 8.13(95% CI: 3.65-18.09) fold increased risk of schizophrenia spectrum disorder. CONCLUSIONS: Carriers of a 22q11.2 deletion who had been clinically identified had a highly increased risk of schizophrenia spectrum disorders.
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