Literature DB >> 26735406

Depleting senescent cells to combat aging.

Hartmut Geiger1.   

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Year:  2016        PMID: 26735406     DOI: 10.1038/nm.4024

Source DB:  PubMed          Journal:  Nat Med        ISSN: 1078-8956            Impact factor:   53.440


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  12 in total

1.  Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.

Authors:  Jean-Philippe Coppé; Francis Rodier; Christopher K Patil; Adam Freund; Pierre-Yves Desprez; Judith Campisi
Journal:  J Biol Chem       Date:  2011-08-31       Impact factor: 5.157

Review 2.  Forging a signature of in vivo senescence.

Authors:  Norman E Sharpless; Charles J Sherr
Journal:  Nat Rev Cancer       Date:  2015-07       Impact factor: 60.716

3.  Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.

Authors:  Chia-Wei Cheng; Gregor B Adams; Laura Perin; Min Wei; Xiaoying Zhou; Ben S Lam; Stefano Da Sacco; Mario Mirisola; David I Quinn; Tanya B Dorff; John J Kopchick; Valter D Longo
Journal:  Cell Stem Cell       Date:  2014-06-05       Impact factor: 24.633

4.  Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer.

Authors:  Charles M Rudin; Christine L Hann; Edward B Garon; Moacyr Ribeiro de Oliveira; Philip D Bonomi; D Ross Camidge; Quincy Chu; Giuseppe Giaccone; Divis Khaira; Suresh S Ramalingam; Malcolm R Ranson; Caroline Dive; Evelyn M McKeegan; Brenda J Chyla; Barry L Dowell; Arunava Chakravartty; Cathy E Nolan; Niki Rudersdorf; Todd A Busman; Mack H Mabry; Andrew P Krivoshik; Rod A Humerickhouse; Geoffrey I Shapiro; Leena Gandhi
Journal:  Clin Cancer Res       Date:  2012-04-11       Impact factor: 12.531

5.  An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.

Authors:  Marco Demaria; Naoko Ohtani; Sameh A Youssef; Francis Rodier; Wendy Toussaint; James R Mitchell; Remi-Martin Laberge; Jan Vijg; Harry Van Steeg; Martijn E T Dollé; Jan H J Hoeijmakers; Alain de Bruin; Eiji Hara; Judith Campisi
Journal:  Dev Cell       Date:  2014-12-11       Impact factor: 12.270

Review 6.  Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.

Authors:  Tamara Tchkonia; Yi Zhu; Jan van Deursen; Judith Campisi; James L Kirkland
Journal:  J Clin Invest       Date:  2013-03-01       Impact factor: 14.808

7.  Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.

Authors:  Jianhui Chang; Yingying Wang; Lijian Shao; Remi-Martin Laberge; Marco Demaria; Judith Campisi; Krishnamurthy Janakiraman; Norman E Sharpless; Sheng Ding; Wei Feng; Yi Luo; Xiaoyan Wang; Nukhet Aykin-Burns; Kimberly Krager; Usha Ponnappan; Martin Hauer-Jensen; Aimin Meng; Daohong Zhou
Journal:  Nat Med       Date:  2015-12-14       Impact factor: 53.440

8.  mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.

Authors:  Chong Chen; Yu Liu; Yang Liu; Pan Zheng
Journal:  Sci Signal       Date:  2009-11-24       Impact factor: 8.192

9.  Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.

Authors:  Maria Carolina Florian; Karin Dörr; Anja Niebel; Deidre Daria; Hubert Schrezenmeier; Markus Rojewski; Marie-Dominique Filippi; Anja Hasenberg; Matthias Gunzer; Karin Scharffetter-Kochanek; Yi Zheng; Hartmut Geiger
Journal:  Cell Stem Cell       Date:  2012-05-04       Impact factor: 24.633

10.  The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

Authors:  Yi Zhu; Tamara Tchkonia; Tamar Pirtskhalava; Adam C Gower; Husheng Ding; Nino Giorgadze; Allyson K Palmer; Yuji Ikeno; Gene B Hubbard; Marc Lenburg; Steven P O'Hara; Nicholas F LaRusso; Jordan D Miller; Carolyn M Roos; Grace C Verzosa; Nathan K LeBrasseur; Jonathan D Wren; Joshua N Farr; Sundeep Khosla; Michael B Stout; Sara J McGowan; Heike Fuhrmann-Stroissnigg; Aditi U Gurkar; Jing Zhao; Debora Colangelo; Akaitz Dorronsoro; Yuan Yuan Ling; Amira S Barghouthy; Diana C Navarro; Tokio Sano; Paul D Robbins; Laura J Niedernhofer; James L Kirkland
Journal:  Aging Cell       Date:  2015-04-22       Impact factor: 9.304

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  2 in total

1.  Discovery of piperlongumine as a potential novel lead for the development of senolytic agents.

Authors:  Yingying Wang; Jianhui Chang; Xingui Liu; Xuan Zhang; Suping Zhang; Xin Zhang; Daohong Zhou; Guangrong Zheng
Journal:  Aging (Albany NY)       Date:  2016-11-19       Impact factor: 5.682

2.  Aging and stress induced β cell senescence and its implication in diabetes development.

Authors:  Na Li; Furong Liu; Ping Yang; Fei Xiong; Qilin Yu; Jinxiu Li; Zhiguang Zhou; Shu Zhang; Cong-Yi Wang
Journal:  Aging (Albany NY)       Date:  2019-11-13       Impact factor: 5.682

  2 in total

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