Literature DB >> 26735294

Anticoagulation in atrial fibrillation: impact of mental illness.

Susan K Schmitt1, Mintu P Turakhia, Ciaran S Phibbs, Rudolf H Moos, Dan Berlowitz, Paul Heidenreich, Vicotr Y Chiu, Alan S Go, Sarah A Friedman, Claire T Than, Susan M Frayne.   

Abstract

OBJECTIVES: To characterize warfarin eligibility and receipt among Veterans Health Administration (VHA) patients with and without mental health conditions (MHCs). STUDY
DESIGN: Retrospective cohort study.
METHODS: This observational study identified VHA atrial fibrillation (AF) patients with and without MHCs in 2004. We examined unadjusted MHC-related differences in warfarin eligibility and warfarin receipt among warfarin-eligible patients, using logistic regression for any MHC and for specific MHCs (adjusting for sociodemographic and clinical characteristics).
RESULTS: Of 125,670 patients with AF, most (96.8%) were warfarin-eligible based on a CHADS2 stroke risk score. High stroke risk and contraindications to anticoagulation were both more common in patients with MHC. Warfarin-eligible patients with MHC were less likely to receive warfarin than those without MHC (adjusted odds ratio [AOR], 0.90; 95% CI, 0.87-0.94). The association between MHC and warfarin receipt among warfarin-eligible patients varied by specific MHC. Patients with anxiety disorders (AOR, 0.86; 95% CI, 0.80-0.93), psychotic disorders (AOR, 0.77; 95% CI, 0.65-0.90), and alcohol use disorders (AOR 0.62, 95% CI 0.54-0.72) were less likely to receive warfarin than patients without these conditions, whereas patients with depressive disorders and posttraumatic stress disorder were no less likely to receive warfarin than patients without these conditions.
CONCLUSIONS: Compared with patients with AF without MHCs, those with MHCs are less likely to be eligible for warfarin receipt and, among those eligible, are less likely to receive such treatment. Although patients with AF with MHC need careful assessment of bleeding risk, this finding suggests potential missed opportunities for more intensive therapy among some individuals with MHCs.

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Year:  2015        PMID: 26735294

Source DB:  PubMed          Journal:  Am J Manag Care        ISSN: 1088-0224            Impact factor:   2.229


  7 in total

1.  Using the Symmetry Analysis Design to Screen for Adverse Effects of Non-vitamin K Antagonist Oral Anticoagulants.

Authors:  Maja Hellfritzsch; Lotte Rasmussen; Jesper Hallas; Anton Pottegård
Journal:  Drug Saf       Date:  2018-07       Impact factor: 5.606

2.  Association Between Bipolar Disorder or Schizophrenia and Oral Anticoagulation Use in Danish Adults With Incident or Prevalent Atrial Fibrillation.

Authors:  Morten Fenger-Grøn; Claus Høstrup Vestergaard; Anette Riisgaard Ribe; Søren Paaske Johnsen; Lars Frost; Annelli Sandbæk; Dimitry S Davydow
Journal:  JAMA Netw Open       Date:  2021-05-03

3.  The effect of mental health conditions on the use of oral anticoagulation therapy in patients with atrial fibrillation: the FinACAF study.

Authors:  Jussi Jaakkola; Konsta Teppo; Fausto Biancari; Olli Halminen; Jukka Putaala; Pirjo Mustonen; Jari Haukka; Miika Linna; Janne Kinnunen; Paula Tiili; Aapo L Aro; Juha Hartikainen; K E Juhani Airaksinen; Mika Lehto
Journal:  Eur Heart J Qual Care Clin Outcomes       Date:  2022-05-05

4.  Anxiety, Depression, and Adverse Clinical Outcomes in Patients With Atrial Fibrillation Starting Warfarin: Cardiovascular Research Network WAVE Study.

Authors:  Christine Baumgartner; Dongjie Fan; Margaret C Fang; Daniel E Singer; Daniel M Witt; John R Schmelzer; Marc S Williams; Jerry H Gurwitz; Sue Hee Sung; Alan S Go
Journal:  J Am Heart Assoc       Date:  2018-04-14       Impact factor: 5.501

5.  Impact of social determinants of health on anticoagulant use among patients with atrial fibrillation: Systemic review and meta-analysis.

Authors:  Rasha Khatib; Nicole Glowacki; John Byrne; Peter Brady
Journal:  Medicine (Baltimore)       Date:  2022-09-02       Impact factor: 1.817

6.  Disparities in oral anticoagulation initiation in patients with schizophrenia and atrial fibrillation: A nationwide cohort study.

Authors:  Anette Arbjerg Højen; Peter Brønnum Nielsen; Sam Riahi; Martin Jensen; Gregory Y H Lip; Torben Bjerregaard Larsen; Mette Søgaard
Journal:  Br J Clin Pharmacol       Date:  2022-04-08       Impact factor: 3.716

7.  Atrial fibrillation in patients with severe mental disorders and the risk of stroke, fatal thromboembolic events and bleeding: a nationwide cohort study.

Authors:  Mette Søgaard; Flemming Skjøth; Jette Nordstrøm Kjældgaard; Torben Bjerregaard Larsen; Søren Pihlkjær Hjortshøj; Sam Riahi
Journal:  BMJ Open       Date:  2017-12-06       Impact factor: 2.692

  7 in total

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