Azizollah Yousefi1, Elham Mahmoudi2, Alireza Zare Bidoki3, Farnaz Najmi Varzaneh2,4, Behnoud Baradaran Noveiry2,4, Maryam Sadr2, Farzaneh Motamed1, Mehri Najafi1, Fatemeh Farahmand1, Nima Rezaei2,4,5. 1. a Department of Gastroenterology, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran. 2. b Molecular Immunology Research Center; Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran. 3. c Thrombosis Hemostasis Research Center , Tehran University of Medical Sciences , Tehran , Iran. 4. d Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) , Universal Scientific Education and Research Network (USERN) , Tehran , Iran. 5. e Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
Abstract
BACKGROUND: Autoimmune hepatitis (AIH) is a chronic long-lasting hepatocellular inflammation associated with circulating auto antibodies. In addition to the genetic component, several cytokines have been implicated to be involved in AIH. This study was performed to investigate potential associations of AIH with IL4 gene variants. METHOD: The studied alleles and genotypes included: IL4G/T allele polymorphisms at position -1098 and C/T allele polymorphisms at two positions (-33 and -590) on the IL4 gene, in addition to the A/G allele polymorphisms at position +1902 on the IL4RA gene. RESULT: The IL4 C allele and CC genotype at position -590 and TT genotype at position -33 had a significantly higher frequency in AIH patients. CONCLUSION: This study identified the IL4 C allele and CC genotype susceptibility gene in AIH, which will provide better insights into the mechanisms of AIH and potential therapeutic interventions.
BACKGROUND:Autoimmune hepatitis (AIH) is a chronic long-lasting hepatocellular inflammation associated with circulating auto antibodies. In addition to the genetic component, several cytokines have been implicated to be involved in AIH. This study was performed to investigate potential associations of AIH with IL4 gene variants. METHOD: The studied alleles and genotypes included: IL4G/T allele polymorphisms at position -1098 and C/T allele polymorphisms at two positions (-33 and -590) on the IL4 gene, in addition to the A/G allele polymorphisms at position +1902 on the IL4RA gene. RESULT: The IL4 C allele and CC genotype at position -590 and TT genotype at position -33 had a significantly higher frequency in AIH patients. CONCLUSION: This study identified the IL4 C allele and CC genotype susceptibility gene in AIH, which will provide better insights into the mechanisms of AIH and potential therapeutic interventions.