| Literature DB >> 26735019 |
Feipeng Liu1, Jiangchun Zhong1, Shuoning Li1, Minyan Li1, Lin Wu1, Qian Wang1, Jianyou Mao1, Shikuo Liu1, Bing Zheng1, Min Wang1, Qinghua Bian1.
Abstract
The first total syntheses of two marine natural products, (R)-strongylodiols C and D, with 99% ee were achieved. The key steps of the strategy include the zipper reaction of an alkyne, the asymmetric alkynylation of an unsaturated aliphatic aldehyde catalyzed with Trost's ProPhenol ligand, and the Cadiot-Chodkiewicz cross-coupling reaction of a chiral propargylic alcohol with a bromoalkyne.Entities:
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Year: 2016 PMID： 26735019 DOI： 10.1021/acs.jnatprod.5b00713
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050