BACKGROUND: The use of plants of the family Euphorbiaceae, particularly Euphorbia tirucalli (avelós) has been popularly widespread for treating a variety of diseases of infectious, tumoral, and inflammatory. AIM: To demonstrated antimicrobial and immunomodulatory effects of these extracts, evaluating the effect of a topical treatment with an aqueous solution of avelós latex on the survival and on intestinal adhesions in rats with experimental peritonitis. METHODS: Peritonitis was induced in 24 Wistar rats, that were randomized into four groups of six as follows: (1) Control group (n=6), no treatment; (2) Antibiotic group (n=6), treatment with a single intramuscular dose of antibiotic Unasyn; (3) Saline group (n=6), the abdominal cavity was washed with 0.9% saline; and (4) E.tirucalli group (n=6), the abdominal cavity was washed with E. tirucalli at a concentration of 12 mg/ml. The animals that died were necropsied, and the time of death was recorded. The survivors were killed on postoperative day 11, and necropsy was subsequently performed for evaluation of the intestinal adhesions. RESULTS: Significant differences were observed in the control and antibiotic groups (p<0.01) with respect to the survival hours when compared with the saline and E. tirucalli groups. There was no significant difference (p>0.05) in the survival of animals in the saline andE. tirucalli groups; however, one animal died in the saline group. Necropsy of the animals in the saline and E. tirucalligroups showed strong adhesions resistant to manipulation, between the intestinal loops and abdominal wall. The remaining groups did not show any adhesions. CONCLUSIONS: Topical treatment with E. tirucalli latex stimulated an increased formation of intestinal adhesions and prevented the death of all animals with peritonitis.
BACKGROUND: The use of plants of the family Euphorbiaceae, particularly Euphorbia tirucalli (avelós) has been popularly widespread for treating a variety of diseases of infectious, tumoral, and inflammatory. AIM: To demonstrated antimicrobial and immunomodulatory effects of these extracts, evaluating the effect of a topical treatment with an aqueous solution of avelós latex on the survival and on intestinal adhesions in rats with experimental peritonitis. METHODS:Peritonitis was induced in 24 Wistar rats, that were randomized into four groups of six as follows: (1) Control group (n=6), no treatment; (2) Antibiotic group (n=6), treatment with a single intramuscular dose of antibiotic Unasyn; (3) Saline group (n=6), the abdominal cavity was washed with 0.9% saline; and (4) E.tirucalli group (n=6), the abdominal cavity was washed with E. tirucalli at a concentration of 12 mg/ml. The animals that died were necropsied, and the time of death was recorded. The survivors were killed on postoperative day 11, and necropsy was subsequently performed for evaluation of the intestinal adhesions. RESULTS: Significant differences were observed in the control and antibiotic groups (p<0.01) with respect to the survival hours when compared with the saline and E. tirucalli groups. There was no significant difference (p>0.05) in the survival of animals in the saline andE. tirucalli groups; however, one animal died in the saline group. Necropsy of the animals in the saline and E. tirucalligroups showed strong adhesions resistant to manipulation, between the intestinal loops and abdominal wall. The remaining groups did not show any adhesions. CONCLUSIONS: Topical treatment with E. tirucallilatex stimulated an increased formation of intestinal adhesions and prevented the death of all animals with peritonitis.
Authors: Doris S Llanes-Coronel; Laura Y Gámez-Díaz; Leidy P Suarez-Quintero; Lady J Páez; Fernando Torres; Fernando Echeverri; Alicia Ponte-Sucre; Pablo J Patiño; Claudia M Trujillo-Vargas Journal: Immunopharmacol Immunotoxicol Date: 2010-07-29 Impact factor: 2.730
Authors: Flávio Kreimer; José Lamartine de Andrade Aguiar; Célia M M B Castro; Cláudio Moura Lacerda; Tarcisio Reis; Fernando Lisboa Júnior Journal: Acta Cir Bras Date: 2005 Impact factor: 1.388
Authors: K E Sands; D W Bates; P N Lanken; P S Graman; P L Hibberd; K L Kahn; J Parsonnet; R Panzer; E J Orav; D R Snydman; E Black; J S Schwartz; R Moore; B L Johnson; R Platt Journal: JAMA Date: 1997-07-16 Impact factor: 56.272
Authors: João Baptista Rezende-Neto; Hélio Machado Vieira; Bruno de Lima Rodrigues; Sandro Rizoli; Barto Nascimento; Gustavo Pereira Fraga Journal: Rev Col Bras Cir Date: 2014 Jan-Feb