Literature DB >> 26734642

Role of microRNAs in chemoresistance.

Peter Magee1, Lei Shi1, Michela Garofalo1.   

Abstract

Drug resistance is a major problem in the treatment of cancer patients. Resistance can develop after prolonged cycles of chemotherapy or can be present intrinsically in the patient. There is an emerging role of microRNAs (miRNAs) in resistance to cancer treatments. miRNAs are small non-coding RNAs that are evolutionarily conserved and also involved as regulators of gene expression through the silencing of mRNA targets. They are involved in many different cancer types and a plethora of mechanisms have been postulated for the roles that miRNAs play in the development of drug resistance. Hence, miRNA-based gene therapy may provide a novel approach for the future of cancer therapy. This review focuses on an overview of recent findings on the role of miRNAs in the resistance to chemotherapy in different tumours.

Entities:  

Keywords:  MicroRNAs (miRNAs); cancer; chemoresistance

Year:  2015        PMID： 26734642      PMCID： PMC4690999          DOI： 10.3978/j.issn.2305-5839.2015.11.32

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN： 2305-5839


  79 in total

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Authors:  Lin He; Gregory J Hannon
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Authors:  Magali Rebucci; Carine Michiels
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Review 3.  Regulatory networks defining EMT during cancer initiation and progression.

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Journal:  Nat Rev Cancer       Date:  2013-02       Impact factor: 60.716

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Journal:  Int J Cancer       Date:  2014-03-03       Impact factor: 7.396

Review 5.  Ovarian cancer: diagnostic, biological and prognostic aspects.

Authors:  Ben Davidson; Claes G Tropé
Journal:  Womens Health (Lond)       Date:  2014-09

6.  The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines.

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Journal:  Cancer Res       Date:  2009-04-07       Impact factor: 12.701

Review 7.  Targeting multidrug resistance in cancer.

Authors:  Gergely Szakács; Jill K Paterson; Joseph A Ludwig; Catherine Booth-Genthe; Michael M Gottesman
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8.  The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer.

Authors:  Yan Ni Loh; Ellen L Hedditch; Laura A Baker; Eve Jary; Robyn L Ward; Caroline E Ford
Journal:  BMC Cancer       Date:  2013-04-02       Impact factor: 4.430

9.  MicroRNA-147 induces a mesenchymal-to-epithelial transition (MET) and reverses EGFR inhibitor resistance.

Authors:  Chang Gong Lee; Susan McCarthy; Mike Gruidl; Cindy Timme; Timothy J Yeatman
Journal:  PLoS One       Date:  2014-01-15       Impact factor: 3.240

10.  miR-29b, miR-205 and miR-221 enhance chemosensitivity to gemcitabine in HuH28 human cholangiocarcinoma cells.

Authors:  Kinya Okamoto; Kenichi Miyoshi; Yoshikazu Murawaki
Journal:  PLoS One       Date:  2013-10-17       Impact factor: 3.240
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  37 in total

1.  Overexpression of microRNA-15 increases the chemosensitivity of colon cancer cells to 5-fluorouracil and oxaliplatin by inhibiting the nuclear factor-κB signalling pathway and inducing apoptosis.

Authors:  Lili Liu; Dan Wang; Ying Qiu; Hongyan Dong; Xuemei Zhan
Journal:  Exp Ther Med       Date:  2017-12-22       Impact factor: 2.447

2.  Involvement of microRNA-141-3p in 5-fluorouracil and oxaliplatin chemo-resistance in esophageal cancer cells via regulation of PTEN.

Authors:  Ying-Ying Jin; Qing-Juan Chen; Kun Xu; Hong-Tao Ren; Xing Bao; Yi-Nan Ma; Yang Wei; Hong Bing Ma
Journal:  Mol Cell Biochem       Date:  2016-09-19       Impact factor: 3.396

3.  Global DNA methylation analysis reveals miR-214-3p contributes to cisplatin resistance in pediatric intracranial nongerminomatous malignant germ cell tumors.

Authors:  Tsung-Han Hsieh; Yun-Ru Liu; Ting-Yu Chang; Muh-Lii Liang; Hsin-Hung Chen; Hsei-Wei Wang; Yun Yen; Tai-Tong Wong
Journal:  Neuro Oncol       Date:  2018-03-27       Impact factor: 12.300

4.  The Effect of miR-200c Inhibition on Chemosensitivity (5- FluoroUracil) in Colorectal Cancer.

Authors:  Korosh Heydari; Massoud Saidijam; Mohammad Reza Sharifi; Fatemeh Karimi Dermani; Sara Soleimani Asl; Nooshin Shabab; Rezvan Najafi
Journal:  Pathol Oncol Res       Date:  2017-04-14       Impact factor: 3.201

Review 5.  The related miRNAs involved in doxorubicin resistance or sensitivity of various cancers: an update.

Authors:  Zahra Torki; Davood Ghavi; Solmaz Hashemi; Yazdan Rahmati; Dara Rahmanpour; Majid Pornour; Mohammad Reza Alivand
Journal:  Cancer Chemother Pharmacol       Date:  2021-09-12       Impact factor: 3.333

6.  MiR-221/222 promote chemoresistance to cisplatin in ovarian cancer cells by targeting PTEN/PI3K/AKT signaling pathway.

Authors:  Zeinab Amini-Farsani; Mohammad Hossein Sangtarash; Mehdi Shamsara; Hossein Teimori
Journal:  Cytotechnology       Date:  2017-09-08       Impact factor: 2.058

Review 7.  The associations and roles of microRNA single-nucleotide polymorphisms in cervical cancer.

Authors:  Yaheng Li; Chuanyin Li; Shuyuan Liu; Jia Yang; Li Shi; Yufeng Yao
Journal:  Int J Med Sci       Date:  2021-04-07       Impact factor: 3.738

8.  Improving Gemcitabine Sensitivity in Pancreatic Cancer Cells by Restoring miRNA-217 Levels.

Authors:  Concetta Panebianco; Nadia Trivieri; Annacandida Villani; Fulvia Terracciano; Tiziana Pia Latiano; Adele Potenza; Francesco Perri; Elena Binda; Valerio Pazienza
Journal:  Biomolecules       Date:  2021-04-26

9.  Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway.

Authors:  Jia-Xing Zhang; Yi Xu; Ying Gao; Cui Chen; Zhou-San Zheng; Miao Yun; Hui-Wen Weng; Dan Xie; Sheng Ye
Journal:  Mol Cancer       Date:  2017-01-23       Impact factor: 27.401

10.  MicroRNA-1246 by Targeting AXIN2 and GSK-3β Overcomes Drug Resistance and Induces Apoptosis in Chemo-resistant Leukemia Cells.

Authors:  Bei Xie; Linjing Li; Zhewen Zhang; Lei Zhao; Juan Cheng; Cunmin Zhou; Jie Cheng; Jing Yan; Jing Chen; Juan Yi; Bei Wang; Suya Jin; Hulai Wei
Journal:  J Cancer       Date:  2021-05-13       Impact factor: 4.207
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