Literature DB >> 26734117

A Head and Neck Support Device for Inducing Local Hypothermia.

Adam Gladen1, Paul A Iaizzo2, John C Bischof3, Arthur G Erdman1, Afshin A Divani3.   

Abstract

The present work describes the design of a device/system intended to induce local mild hypothermia by simultaneously cooling a patient's head and neck. The therapeutic goal is to lower the head and neck temperatures to 33-35 °C, while leaving the core body temperature unchanged. The device works by circulating a cold fluid around the exterior of the head and neck. The head surface area is separated into five different cooling zones. Each zone has a cooling coil and can be independently controlled. The cooling coils are tightly wrapped concentric circles of tubing. This design allows for a dense packing of tubes in a limited space, while preventing crimping of the tubing and minimizing the fluid pressure head loss. The design in the neck region also has multiple tubes wrapping around the circumference of the patient's neck in a helix. Preliminary testing indicates that this approach is capable of achieving the design goal of cooling the brain tissue (at a depth of 2.5 cm from the scalp) to 35 °C within 30- 40 min, without any pharmacologic or circulatory manipulation. In a comparison with examples of current technology, the device has shown the potential for improved cooling capability.

Entities:  

Keywords:  cooling helmet; hypothermia; neuroprotection; stroke; traumatic brain injury

Year:  2013        PMID: 26734117      PMCID: PMC4690010          DOI: 10.1115/1.4025448

Source DB:  PubMed          Journal:  J Med Device        ISSN: 1932-6181            Impact factor:   0.582


  44 in total

1.  Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke.

Authors:  D W Krieger; M A De Georgia; A Abou-Chebl; J C Andrefsky; C A Sila; I L Katzan; M R Mayberg; A J Furlan
Journal:  Stroke       Date:  2001-08       Impact factor: 7.914

2.  Effects of selective brain cooling in patients with severe traumatic brain injury: a preliminary study.

Authors:  W G Liu; W S Qiu; Y Zhang; W M Wang; F Lu; X F Yang
Journal:  J Int Med Res       Date:  2006 Jan-Feb       Impact factor: 1.671

Review 3.  Therapeutic hypothermia and controlled normothermia in the intensive care unit: practical considerations, side effects, and cooling methods.

Authors:  Kees H Polderman; Ingeborg Herold
Journal:  Crit Care Med       Date:  2009-03       Impact factor: 7.598

4.  Immediate or delayed mild hypothermia prevents focal cerebral infarction.

Authors:  D Xue; Z G Huang; K E Smith; A M Buchan
Journal:  Brain Res       Date:  1992-07-31       Impact factor: 3.252

5.  A mathematical model for human brain cooling during cold-water near-drowning.

Authors:  X Xu; P Tikuisis; G Giesbrecht
Journal:  J Appl Physiol (1985)       Date:  1999-01

6.  Neuroprotection of hypothermia against neuronal death in rat hippocampus through inhibiting the increased assembly of GluR6-PSD95-MLK3 signaling module induced by cerebral ischemia/reperfusion.

Authors:  Wei-Wei Hu; Yang Du; Chong Li; Yuan-Jian Song; Guang-Yi Zhang
Journal:  Hippocampus       Date:  2008       Impact factor: 3.899

7.  Brain temperature and limits on transcranial cooling in humans: quantitative modeling results.

Authors:  D A Nelson; S A Nunneley
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1998-09

Review 8.  Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic review.

Authors:  Lauralyn A McIntyre; Dean A Fergusson; Paul C Hébert; David Moher; James S Hutchison
Journal:  JAMA       Date:  2003-06-11       Impact factor: 56.272

Review 9.  Cooling therapy for acute stroke.

Authors:  Heleen M Den Hertog; H Bart van der Worp; Mei-Chiun Tseng; Diederik Wj Dippel
Journal:  Cochrane Database Syst Rev       Date:  2009-01-21

10.  Efficacy of and tolerance to mild induced hypothermia after out-of-hospital cardiac arrest using an endovascular cooling system.

Authors:  Nicolas Pichon; Jean Bernard Amiel; Bruno François; Anthony Dugard; Caroline Etchecopar; Philippe Vignon
Journal:  Crit Care       Date:  2007       Impact factor: 9.097

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  2 in total

1.  Selective brain hypothermia: feasibility and safety study of a novel method in five patients.

Authors:  Seyed Mohammad Seyedsaadat; Silvana F Marasco; David J Daly; Robin McEgan; James Anderson; Seth Rodgers; Thomas Kreck; Ramanathan Kadirvel; David F Kallmes
Journal:  Perfusion       Date:  2019-06-26       Impact factor: 1.972

2.  Selective Brain Hypothermia in Acute Ischemic Stroke: Reperfusion Without Reperfusion Injury.

Authors:  Jae H Choi; Sven Poli; Michael Chen; Thanh N Nguyen; Jeffrey L Saver; Charles Matouk; John Pile-Spellman
Journal:  Front Neurol       Date:  2020-11-13       Impact factor: 4.003

  2 in total

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