Literature DB >> 26733519

Treatment of nonunions in fractures of the humeral shaft according to the Diamond Concept.

M Miska1, S Findeisen1, M Tanner1, B Biglari2, S Studier-Fischer2, P A Grützner2, G Schmidmaier1, A Moghaddam1.   

Abstract

METHODS: Between 2005 and 2012, 50 patients (23 female, 27 male) with nonunion of the humeral shaft were included in this retrospective study. The mean age was 51.3 years (14 to 88). The patients had a mean of 1.5 prior operations (sd 1.2;1 to 8). All patients were assessed according to a specific risk score in order to devise an optimal and individual therapy plan consistent with the Diamond Concept. In 32 cases (64%), a change in the osteosynthesis to an angular stable locking compression plate was performed. According to the individual risk an additional bone graft and/or bone morphogenetic protein-7 (BMP-7) were applied.
RESULTS: A successful consolidation of the nonunion was observed in 37 cases (80.4%) with a median healing time of six months (IQR 6). Younger patients showed significantly better consolidation. Four patients were lost to follow-up. Revision was necessary in a total of eight (16%) cases. In the initial treatment, intramedullary nailing was most common. DISCUSSION: The use of locking compression plates in combination with autologous cancellous bone graft has been shown to be a safe and effective treatment. In more complex cases, the use of the Masquelet technique and BMP-7 may be indicated at the first revision operation. TAKE HOME MESSAGE: Our results suggest the Diamond Concept is a successful treatment strategy for nonunions of the humeral shaft. ©2016 The British Editorial Society of Bone & Joint Surgery.

Entities:  

Keywords:  Diamond Concept; Fracture Healing; Fracture of the Humeral Shaft; Nonunion; Pseudoarthrosis

Mesh:

Year:  2016        PMID: 26733519     DOI: 10.1302/0301-620X.98B1.35682

Source DB:  PubMed          Journal:  Bone Joint J        ISSN: 2049-4394            Impact factor:   5.082


  19 in total

1.  Low intensity pulsed ultrasound in the treatment of long bone nonunions: Evaluation of cytokine expression as a tool for objectifying nonunion therapy.

Authors:  Arash Moghaddam; Timur Mert Yildirim; Fabian Westhauser; Wolfgang Danner; Tyler Swing; Thomas Bruckner; Bahram Biglari
Journal:  J Orthop       Date:  2016-07-02

2.  [Tibial defects and infected non-unions : Treatment results after Masquelet technique].

Authors:  A Moghaddam; C Ermisch; C Fischer; S Zietzschmann; G Schmidmaier
Journal:  Orthopade       Date:  2017-03       Impact factor: 1.087

Review 3.  Diaphyseal long bone nonunions - types, aetiology, economics, and treatment recommendations.

Authors:  Markus Rupp; Christoph Biehl; Matthäus Budak; Ulrich Thormann; Christian Heiss; Volker Alt
Journal:  Int Orthop       Date:  2017-12-22       Impact factor: 3.075

4.  Three-dimensional polymer coated 45S5-type bioactive glass scaffolds seeded with human mesenchymal stem cells show bone formation in vivo.

Authors:  Fabian Westhauser; Christian Weis; Matthäus Prokscha; Leonie A Bittrich; Wei Li; Kai Xiao; Ulrich Kneser; Hans-Ulrich Kauczor; Gerhard Schmidmaier; Aldo R Boccaccini; Arash Moghaddam
Journal:  J Mater Sci Mater Med       Date:  2016-06-07       Impact factor: 3.896

5.  [Pseudarthroses of the long bones].

Authors:  J Everding; S Roßlenbroich; M J Raschke
Journal:  Chirurg       Date:  2018-01       Impact factor: 0.955

6.  Bone marrow aspirate concentrate/platelet-rich fibrin augmentation accelerates healing of aseptic upper limb nonunions.

Authors:  Alessandro Mazzotta; Cesare Stagni; Martina Rocchi; Nicola Rani; Nicolandrea Del Piccolo; Giuseppe Filardo; Dante Dallari
Journal:  J Orthop Traumatol       Date:  2021-06-05

7.  Safety study: is there a pathologic IGF-1, PDGF and TGF-β cytokine expression caused by adjunct BMP-7 in tibial and femoral non-union therapy?

Authors:  Christian Fischer; Christian Reiner; Gerhard Schmidmaier; Julian Doll; Christopher Child; Paul Alfred Grützner; Bahram Biglari; Sonja Boxriker; Arash Moghaddam
Journal:  Ther Clin Risk Manag       Date:  2018-04-16       Impact factor: 2.423

8.  Evaluation of the clinical effectiveness of bioactive glass (S53P4) in the treatment of non-unions of the tibia and femur: study protocol of a randomized controlled non-inferiority trial.

Authors:  Michael C Tanner; Raban Heller; Fabian Westhauser; Matthias Miska; Thomas Ferbert; Christian Fischer; Simone Gantz; Gerhard Schmidmaier; Patrick Haubruck
Journal:  Trials       Date:  2018-05-30       Impact factor: 2.279

9.  Treatment with recombinant human bone morphogenetic protein 7 leads to a transient induction of neutralizing autoantibodies in a subset of patients.

Authors:  Andrea Schuette; Arash Moghaddam; Petra Seemann; Georg N Duda; Gerhard Schmidmaier; Lutz Schomburg
Journal:  BBA Clin       Date:  2016-08-03

10.  Patients' safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use?

Authors:  Arash Moghaddam; Viola Graeser; Fabian Westhauser; Ulrike Dapunt; Till Kamradt; Stefan M Woerner; Gerhard Schmidmaier
Journal:  Ther Clin Risk Manag       Date:  2016-09-07       Impact factor: 2.423

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