Literature DB >> 26732928

[Obesity as a risk factor in the development of cancer].

Deissy Herrera-Covarrubias1, Genaro Alfonso Coria-Avila1, Cynthia Fernández-Pomares1, Gonzalo E Aranda-Abreu1, Jorge Manzo Denes1, María Elena Hernández1.   

Abstract

According to the World Health Organization, every year about 3.4 million adults die of consequences related to overweight or obesity. People with a Body Mass Index above 30 are more likely to express certain diseases, including some types of cancer. In this narrative review, we assess the role of adipose tissue as a modulator of the endocrine system and facilitator of chronic subclinical inflammation. We discuss how obesity can induce a suitable micro environment for the development of tumors, mainly by enhancing the levels of oxidative stress and the concentrations of hormones such as leptin, insulin and prolactin. We conclude that all together, these factors increase the probability of cancer development.

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Year:  2015        PMID: 26732928

Source DB:  PubMed          Journal:  Rev Peru Med Exp Salud Publica        ISSN: 1726-4634


  3 in total

1.  Autocrined leptin promotes proliferation of non-small cell lung cancer (NSCLC) via PI3K/AKT and p53 pathways.

Authors:  Jin Wang; Fachen Zhou; Fengzhou Li; Bing Wang; Yiying Hu; Xia Li
Journal:  Ann Transl Med       Date:  2021-04

2.  Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People.

Authors:  Abidullah Khan; Wazir Muhammad Khan; Maimoona Ayub; Mohammad Humayun; Mohammad Haroon
Journal:  J Obes       Date:  2016-12-27

Review 3.  Anti-Obesity Effects of Macroalgae.

Authors:  Saioa Gómez-Zorita; Maitane González-Arceo; Jenifer Trepiana; Itziar Eseberri; Alfredo Fernández-Quintela; Iñaki Milton-Laskibar; Leixuri Aguirre; Marcela González; María P Portillo
Journal:  Nutrients       Date:  2020-08-08       Impact factor: 5.717

  3 in total

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