Rui Zhao1, Yan Li2, Wen Dai1.
Abstract
BACKGROUND: Cystatin C, a marker for early stage chronic kidney dysfunction, mediates the pathogenesis of cardiovascular diseases.
OBJECTIVE: To investigate whether serum cystatin C is an independent predictor of coronary heart disease (CHD) for patients without chronic kidney disease (CKD).
METHODS: In this cross-sectional study, we included 525 patients with CHD and 142 apparently healthy control individuals and acquired their demographic characteristics, medical histories, and listings of the concurrent medications they were taking. All patients with CHD underwent coronary angiography and other routine laboratory examinations. We quantified serum concentrations of cystatin C via particle-enhanced immunonephelometric assay.
RESULTS: Compared with controls, the patients with CHD had higher serum cystatin C levels (median: 1.17 mg/L, interquartile range [IQR]: 1.01 to 1.46 mg/L vs median: 0.98 mg/L, IQR: 0.80 to 1.06 mg/L, P <.001), lower levels of high-density lipoprotein cholesterol (P <.001), higher levels of low-density lipoprotein cholesterol (P <.001), triglyceride (P <.001), total cholesterol (P = .007) and high-sensitivity C-reactive protein (P <.001). No differences occurred in serum concentrations of creatinine or estimated glomerular filtration rate between CHD patients and healthy controls. Multivariate logistic regression indicated that levels of cystatin C (OR, 1.648; 95% confidence interval [CI], 1.454 to 1.868; P <.001) were most strongly correlated with CHD prevalence.
CONCLUSIONS: Elevated serum cystatin C is a potential biochemical marker for the prediction of CHD, which suggests that mild preclinical renal dysfunction may be associated with the pathogenesis of CHD. © American Society for Clinical Pathology, 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
BACKGROUND: Cystatin C, a marker for early stage chronic kidney dysfunction, mediates the pathogenesis of cardiovascular diseases.
OBJECTIVE: To investigate whether serum cystatin C is an independent predictor of coronary heart disease (CHD) for patients without chronic kidney disease (CKD).
METHODS: In this cross-sectional study, we included 525 patients with CHD and 142 apparently healthy control individuals and acquired their demographic characteristics, medical histories, and listings of the concurrent medications they were taking. All patients with CHD underwent coronary angiography and other routine laboratory examinations. We quantified serum concentrations of cystatin C via particle-enhanced immunonephelometric assay.
RESULTS: Compared with controls, the patients with CHD had higher serum cystatin C levels (median: 1.17 mg/L, interquartile range [IQR]: 1.01 to 1.46 mg/L vs median: 0.98 mg/L, IQR: 0.80 to 1.06 mg/L, P <.001), lower levels of high-density lipoprotein cholesterol (P <.001), higher levels of low-density lipoprotein cholesterol (P <.001), triglyceride (P <.001), total cholesterol (P = .007) and high-sensitivity C-reactive protein (P <.001). No differences occurred in serum concentrations of creatinine or estimated glomerular filtration rate between CHD patients and healthy controls. Multivariate logistic regression indicated that levels of cystatin C (OR, 1.648; 95% confidence interval [CI], 1.454 to 1.868; P <.001) were most strongly correlated with CHD prevalence.
CONCLUSIONS: Elevated serum cystatin C is a potential biochemical marker for the prediction of CHD, which suggests that mild preclinical renal dysfunction may be associated with the pathogenesis of CHD. © American Society for Clinical Pathology, 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Entities:
Keywords:
chronic kidney disease; coronary heart disease; cystatin C; glomerular filtration rate
Mesh：
Substances：
Year: 2016
PMID： 26732777 DOI： 10.1093/labmed/lmv004
Source DB: PubMed Journal: Lab Med ISSN： 0007-5027