Literature DB >> 26731665

Cytochrome P450 for Citreohybridonol Synthesis: Oxidative Derivatization of the Andrastin Scaffold.

Yudai Matsuda1, Zhiyang Quan1, Takaaki Mitsuhashi1, Chang Li1, Ikuro Abe1.   

Abstract

A biosynthetic gene cluster similar to that for andrastin A (1) was discovered in Emericella variecolor NBRC 32302. Ctr-P450, a cytochrome P450 uniquely present in the cluster, was coexpressed with the andrastin A biosynthetic genes, leading to the production of the antifeedant agent citreohybridonol (4), along with four new andrastin derivatives. The results revealed the unusual multifunctionality of Ctr-P450 and indicated that this approach can be applied for further natural product diversification.

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Year:  2016        PMID： 26731665     DOI： 10.1021/acs.orglett.5b03465

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Traversing Biosynthetic Carbocation Landscapes in the Total Synthesis of Andrastin and Terretonin Meroterpenes.

Authors:  Gong Xu; Masha Elkin; Dean J Tantillo; Timothy R Newhouse; Thomas J Maimone
Journal:  Angew Chem Int Ed Engl       Date:  2017-08-30       Impact factor: 15.336

2.  Hemiacetalmeroterpenoids A-C and Astellolide Q with Antimicrobial Activity from the Marine-Derived Fungus Penicillium sp. N-5.

Authors:  Tao Chen; Wencong Yang; Taobo Li; Yihao Yin; Yufeng Liu; Bo Wang; Zhigang She
Journal:  Mar Drugs       Date:  2022-08-13       Impact factor: 6.085

3.  Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids.

Authors:  Takaaki Mitsuhashi; Lena Barra; Zachary Powers; Volga Kojasoy; Andrea Cheng; Feng Yang; Yoshimasa Taniguchi; Takashi Kikuchi; Makoto Fujita; Dean J Tantillo; John A Porco; Ikuro Abe
Journal:  Angew Chem Int Ed Engl       Date:  2020-10-22       Impact factor: 15.336

4.  New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.

Authors:  Jinwei Ren; Ruiyun Huo; Gaoran Liu; Ling Liu
Journal:  Mar Drugs       Date:  2021-03-27       Impact factor: 5.118

Review 5.  Biosynthesis of Fungal Natural Products Involving Two Separate Pathway Crosstalk.

Authors:  Guangzhi Dai; Qiyao Shen; Youming Zhang; Xiaoying Bian
Journal:  J Fungi (Basel)       Date:  2022-03-21
  5 in total

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