Literature DB >> 26731605

Subacute effects of low dose lead nitrate and mercury chloride exposure on kidney of rats.

Fatma Gökçe Apaydın1, Hatice Baş2, Suna Kalender3, Yusuf Kalender4.   

Abstract

Lead nitrate and mercury chloride are the most common heavy metal pollutants. In the present study, the effects of lead and mercury induced nephrotoxicity were studied in Wistar rats. Lead nitrate (LN, 45 mg/kg b.w/day) and mercury chloride (MC, 0.02 mg/kg b.w/day) and their combination were administered orally for 28 days. Four groups of rats were used in the study: control, LN, MC and LN plus MC groups. Serum biochemical parameters, lipid peroxidation, antioxidant enzymes and histopathological changes in kidney tissues were investigated in all treatment groups. LN and MC caused severe histopathological changes. It was shown that LN, MC and also co-treatment with LN and MC exposure induced significant increase in serum urea, uric acid and creatinine levels. There were also statistically significant changes in antioxidant enzyme activities (SOD, CAT, GPx and GST) and lipid peroxidation (MDA) in all groups except control group. In this study, we showed that MC caused more harmful effects than LN in rats.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Biochemical parameters; Histopathology; Kidney; Lead nitrate; Mercury chloride; Oxidative stress

Mesh：

Substances：

Year:  2015        PMID： 26731605     DOI： 10.1016/j.etap.2015.12.003

Source DB:  PubMed          Journal:  Environ Toxicol Pharmacol        ISSN： 1382-6689            Impact factor:   4.860


  7 in total

1.  Histopathological and biochemical studies on the effect of curcumin and taurine against bisphenol A toxicity in male rats.

Authors:  Fatma Gökçe Apaydin; Ayşe Aslanturk; Meltem Uzunhisarcikli; Hatice Bas; Suna Kalender; Yusuf Kalender
Journal:  Environ Sci Pollut Res Int       Date:  2019-03-06       Impact factor: 4.223

2.  Association of textile industry effluent with mutagenicity and its toxic health implications upon acute and sub-chronic exposure.

Authors:  Muhammad Furqan Akhtar; Muhammad Ashraf; Aqeel Javeed; Aftab Ahmad Anjum; Ali Sharif; Mohammad Saleem; Ghulam Mustafa; Moneeb Ashraf; Ammara Saleem; Bushra Akhtar
Journal:  Environ Monit Assess       Date:  2018-02-28       Impact factor: 2.513

3.  Luteolin protects against lead acetate-induced nephrotoxicity through antioxidant, anti-inflammatory, anti-apoptotic, and Nrf2/HO-1 signaling pathways.

Authors:  Alaa Jameel A Albarakati; Roua S Baty; Ahmad M Aljoudi; Ola A Habotta; Ehab K Elmahallawy; Rami B Kassab; Ahmed E Abdel Moneim
Journal:  Mol Biol Rep       Date:  2020-03-07       Impact factor: 2.316

4.  Association between Blood Mercury Levels and Non-Alcoholic Fatty Liver Disease in Non-Obese Populations: The Korean National Environmental Health Survey (KoNEHS) 2012-2014.

Authors:  Yun-Jung Yang; Eun-Jung Yang; Kyongjin Park; Subin Oh; Taehyen Kim; Yeon-Pyo Hong
Journal:  Int J Environ Res Public Health       Date:  2021-06-13       Impact factor: 3.390

5.  Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats.

Authors:  Sunday Aderemi Adelakun; Victor Okoliko Ukwenya; Grace Temitope Akingbade; Olusegun Dare Omotoso; Julius Akomaye Aniah
Journal:  Biomed J       Date:  2020-05-06       Impact factor: 4.910

6.  Antioxidant and nephro-protective effect of Juglans regia vegetable oil against lead-induced nephrotoxicity in rats and its characterization by GC-MS.

Authors:  Ahlem Soussi; Manel Gargouri; Amel Akrouti; Abdelfattah El Feki
Journal:  EXCLI J       Date:  2018-05-23       Impact factor: 4.068

7.  Alteration in thiols homeostasis, protein and lipid peroxidation in renal tissue following subacute oral exposure of imidacloprid and arsenic in Wistar rats.

Authors:  Lakshay Mahajan; Pawan Kumar Verma; Rajinder Raina; Nrip K Pankaj; Shilpa Sood; Maninder Singh
Journal:  Toxicol Rep       Date:  2018-11-03
  7 in total

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