Daniel Gordin1, Markku Saraheimo1, Jaana Tuomikangas1, Aino Soro-Paavonen1, Carol Forsblom1, Karri Paavonen1, Birgit Steckel-Hamann1, Francois Vandenhende1, Loizos Nicolaou1, Imre Pavo1, Veikko Koivisto1, Per-Henrik Groop1. 1. Folkhälsan Institute of Genetics (D.G., M.S., J.T., A.S.-P., C.F., K.P., P.-H.G.), Folkhälsan Research Center, Biomedicum Helsinki, FI-00014 Helsinki, Finland; Abdominal Center Nephrology FI-00290 (D.G., M.S., J.T., A.S.-P., C.F., P.-H.G.), University of Helsinki and Helsinki University Hospital, and Research Program Unit (D.G., M.S., J.T., A.S.-P., C.F., P.-H.G.), Department of Diabetes and Obesity, University of Helsinki FI-00014, and Division of Cardiology (K.P.), Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland; Eli Lilly Export SA (B.S.-H.), Vernier, 1214 Geneva, Switzerland; ClinBAY (F.V., L.N.), 1470 Genappe, Belgium; Eli Lilly (I.P.), A-1030 Vienna, Austria; Eli Lilly (V.K.), 00330 Helsinki, Finland; and Baker IDI and Diabetes Institute (P.-H.G.), Melbourne, 3004 Victoria, Australia.
Abstract
CONTEXT: Patients with type 2 diabetes (T2D) are at an increased risk of cardiovascular disease. OBJECTIVE: The objective of the study was to determine whether postprandial hyperglycemia affects arterial function in T2D. DESIGN: A single-center, open-label study of three groups of men were studied: 1) T2D patients with albuminuria (n = 22), 2) T2D patients without albuminuria (n = 24), and 3) nondiabetic controls (n = 25). Patients were randomized to a two-period crossover study schedule, ingesting breakfast, with or without insulin lispro (to induce low or high postprandial glycemia). MAIN OUTCOME MEASURES: Arterial stiffness was assessed by calculating pulse wave velocity (PWV) and augmentation index using applanation tonometry, and endothelial dysfunction was assessed using peripheral arterial tonometry, 30 minutes before breakfast and up to 240 minutes after breakfast. RESULTS: At baseline, arterial stiffness was increased in patients. When adjusted for age and body mass index, in a combined group of patients with and without albuminuria, brachial PWV was higher during low (P = .032) and high (P = .038) postprandial glycemia vs controls. These differences were driven by the albuminuria group vs controls during low (P = .014) and high (P = .018) postprandial glycemia. No differences were observed in aortic PWV, augmentation index, or peripheral arterial tonometry ratio between patients and controls. Endothelin-1 and IL-6 were higher, and superoxide dismutase was lower, during postprandial hyperglycemia in T2D patients vs controls. CONCLUSIONS: In patients with T2D and albuminuria, brachial PWV was higher under postprandial hyperglycemic conditions, relative to controls. These data suggest that hyperglycemia induces an increase in stiffness of intermediate-sized arteries. We found no changes in other parts of the arterial bed.
RCT Entities:
CONTEXT: Patients with type 2 diabetes (T2D) are at an increased risk of cardiovascular disease. OBJECTIVE: The objective of the study was to determine whether postprandial hyperglycemia affects arterial function in T2D. DESIGN: A single-center, open-label study of three groups of men were studied: 1) T2D patients with albuminuria (n = 22), 2) T2D patients without albuminuria (n = 24), and 3) nondiabetic controls (n = 25). Patients were randomized to a two-period crossover study schedule, ingesting breakfast, with or without insulin lispro (to induce low or high postprandial glycemia). MAIN OUTCOME MEASURES: Arterial stiffness was assessed by calculating pulse wave velocity (PWV) and augmentation index using applanation tonometry, and endothelial dysfunction was assessed using peripheral arterial tonometry, 30 minutes before breakfast and up to 240 minutes after breakfast. RESULTS: At baseline, arterial stiffness was increased in patients. When adjusted for age and body mass index, in a combined group of patients with and without albuminuria, brachial PWV was higher during low (P = .032) and high (P = .038) postprandial glycemia vs controls. These differences were driven by the albuminuria group vs controls during low (P = .014) and high (P = .018) postprandial glycemia. No differences were observed in aortic PWV, augmentation index, or peripheral arterial tonometry ratio between patients and controls. Endothelin-1 and IL-6 were higher, and superoxide dismutase was lower, during postprandial hyperglycemia in T2D patients vs controls. CONCLUSIONS: In patients with T2D and albuminuria, brachial PWV was higher under postprandial hyperglycemic conditions, relative to controls. These data suggest that hyperglycemia induces an increase in stiffness of intermediate-sized arteries. We found no changes in other parts of the arterial bed.
Authors: Elizabeth Grey; Chris Bratteli; Stephen P Glasser; Cheryl Alinder; Stanley M Finkelstein; Bruce R Lindgren; Jay N Cohn Journal: Am J Hypertens Date: 2003-04 Impact factor: 2.689
Authors: S Laurent; P Boutouyrie; R Asmar; I Gautier; B Laloux; L Guize; P Ducimetiere; A Benetos Journal: Hypertension Date: 2001-05 Impact factor: 10.190
Authors: M Hanefeld; S Fischer; U Julius; J Schulze; U Schwanebeck; H Schmechel; H J Ziegelasch; J Lindner Journal: Diabetologia Date: 1996-12 Impact factor: 10.122
Authors: Jeffrey T Kuvin; Ayan R Patel; Kathleen A Sliney; Natesa G Pandian; Jacob Sheffy; Robert P Schnall; Richard H Karas; James E Udelson Journal: Am Heart J Date: 2003-07 Impact factor: 4.749
Authors: Daniel P Credeur; Leryn J Reynolds; Seth W Holwerda; Jennifer R Vranish; Benjamin E Young; Jing Wang; John P Thyfault; Paul J Fadel Journal: Exp Physiol Date: 2018-02-14 Impact factor: 2.969
Authors: Wen Lun Yuan; Jinjie Lin; Michael S Kramer; Keith M Godfrey; Peter D Gluckman; Yap-Seng Chong; Lynette P Shek; Kok Hian Tan; Shiao-Yng Chan; Johan G Eriksson; Fabian Yap; Yung Seng Lee; Jonathan T L Choo; Lieng Hsi Ling Journal: J Clin Endocrinol Metab Date: 2020-07-01 Impact factor: 6.134
Authors: Natalia Sanchez-Aguadero; Maria C Patino-Alonso; Sara Mora-Simon; Manuel A Gomez-Marcos; Rosario Alonso-Dominguez; Benigna Sanchez-Salgado; Jose I Recio-Rodriguez; Luis Garcia-Ortiz Journal: Nutrients Date: 2017-07-07 Impact factor: 5.717
Authors: Kaitlin M Love; William B Horton; James T Patrie; Linda A Jahn; Lee M Hartline; Eugene J Barrett Journal: BMJ Open Diabetes Res Care Date: 2022-01