Aileen Y Chang1, Christopher J Miller, Rosalie Elenitsas, Jason G Newman, Joseph F Sobanko. 1. *Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania; †Division of Dermatologic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania; ‡Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania.
Abstract
BACKGROUND: Extraocular sebaceous carcinoma (SC) is a rare malignancy with metastatic potential. The authors present a case of a rapidly growing extraocular SC with equivocal radiographic imaging to highlight challenges in tumor management. OBJECTIVE: To examine the existing literature for evaluation and management recommendations of extraocular SC. METHODS AND MATERIALS: A comprehensive review of relevant English articles in PubMed through May 2015. RESULTS: Tumor-specific staging system and management guidelines do not currently exist for extraocular SC. Mohs micrographic surgery or wide local excision are the most commonly used surgical treatments. Regional/distant metastasis occurs infrequently, but systemic workup with radiographic imaging or sentinel lymph node biopsy may be warranted in select cases. Adjuvant radiation therapy can be considered for recurrent and metastatic tumors. CONCLUSION: Extraocular SCs present unique challenges that may benefit from multidisciplinary management. Surgical removal with negative pathologic margins is the mainstay treatment of extraocular SC. Additional studies will help clarify the optimal diagnostic workup and adjuvant treatment of patients.
BACKGROUND:Extraocular sebaceous carcinoma (SC) is a rare malignancy with metastatic potential. The authors present a case of a rapidly growing extraocular SC with equivocal radiographic imaging to highlight challenges in tumor management. OBJECTIVE: To examine the existing literature for evaluation and management recommendations of extraocular SC. METHODS AND MATERIALS: A comprehensive review of relevant English articles in PubMed through May 2015. RESULTS:Tumor-specific staging system and management guidelines do not currently exist for extraocular SC. Mohs micrographic surgery or wide local excision are the most commonly used surgical treatments. Regional/distant metastasis occurs infrequently, but systemic workup with radiographic imaging or sentinel lymph node biopsy may be warranted in select cases. Adjuvant radiation therapy can be considered for recurrent and metastatic tumors. CONCLUSION: Extraocular SCs present unique challenges that may benefit from multidisciplinary management. Surgical removal with negative pathologic margins is the mainstay treatment of extraocular SC. Additional studies will help clarify the optimal diagnostic workup and adjuvant treatment of patients.
Authors: Eva Huis In 't Veld; Ronald Keizer; Nicoline Post; Jeroen Versteeg; Robert Verdijk; Nicole Naus; Germaine Relyveld; Marianne Crijns; Myles Smith; Dirk Grünhagen; Marlies Wakkee; Dion Paridaens; Ioannis Zavrakidis; Antien Mooyaart; Alexander van Akkooi; Dirk Strauss; Cornelis Verhoef; Michel Wouters; Andrew Hayes; Winan van Houdt Journal: J Surg Oncol Date: 2022-01-06 Impact factor: 2.885