Literature DB >> 26730758

Autologous tracheal replacement for cancer.

Dominique Fabre1, Elie Fadel2, Sacha Mussot2, Frederic Kolb2, Nicolas Leymarie2, Olaf Mercier2, Thierry Le Chevalier2, Philippe G Dartevelle2.   

Abstract

Surgical research has failed during fifty years to find an ideal substitute for the trachea after extended resection. All the prostheses could erode the adjacent structures or lead to infection or obstructive issues. Innovation in surgery development has been improved using novel techniques of plastic surgery. During the last ten years, we have developed a technique using free fasciocutaneous flaps. This allows us to construct tubes for tracheal replacement. The most accurate flap used for this technique is the forearm free flap (FFF). Reinforcement of the flap with autologous strips of cartilage harvested from the last ribs offers sufficient resistance to respiratory pressure. This technique is also completely autologous without any stent in the tracheal lumen. From 2004 to 2015 we have already reconstructed the trachea of 16 patients for 12 primary tracheal neoplasms [including 9 adenoid cystic carcinoma (ACC) and 3 squamous cell carcinoma (SCC)], 3 secondary tracheal Neoplasms and one for benign lesion. This article describes the indications, determination of resectability, patient selection, subheading for surgery, postoperative management and results of this technique.

Entities:  

Keywords:  Adenoid cystic carcinoma (ACC); autologous replacemen; forearm free flap (FFF); squamous cell carcinoma (SCC); trachea

Mesh:

Year:  2015        PMID: 26730758     DOI: 10.3978/j.issn.2304-3865.2015.12.07

Source DB:  PubMed          Journal:  Chin Clin Oncol        ISSN: 2304-3865


  3 in total

1.  Repair of large airway defects with bioprosthetic materials.

Authors:  Francesco Petrella; Lorenzo Spaggiari
Journal:  J Thorac Dis       Date:  2017-10       Impact factor: 2.895

Review 2.  The Growing Medical Need for Tracheal Replacement: Reconstructive Strategies Should Overcome Their Limits.

Authors:  Davide Adamo; Giulia Galaverni; Vincenzo Giuseppe Genna; Filippo Lococo; Graziella Pellegrini
Journal:  Front Bioeng Biotechnol       Date:  2022-05-09

Review 3.  Reconstruction of the trachea and carina: Surgical reconstruction, autologous tissue transplantation, allograft transplantation, and bioengineering.

Authors:  Jianghao Ren; Yuanyuan Xu; Guo Zhiyi; Ting Ren; Jiangbin Ren; Kan Wang; Yiqing Luo; Mingyang Zhu; Qiang Tan
Journal:  Thorac Cancer       Date:  2022-01-13       Impact factor: 3.500

  3 in total

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